Context dependence of proneural bHLH proteins

被引：78

作者：

Powell, Lynn M. ^{[1
]}

Jarman, Andrew P. ^{[1
]}

机构：

[1] Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2008年 / 18卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.gde.2008.07.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A key point in neural development is the commitment of progenitor cells to a specific neural fate. In all animals studied, proneural proteins - transcription factors of the basic helix-loop-helix (bHLH) family - are central to this process. The function of these factors is strongly influenced by the spatial and temporal context in which they are expressed. It is important to understand the molecular mechanisms by which developmental context interacts with and modifies the intrinsic functions and properties of the proneural proteins. Recent insights have been obtained in Drosophila and vertebrates from analysis of how bHLH proteins interact with other transcription factors to regulate target genes.

引用

页码：411 / 417

页数：7

共 58 条

[1] Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator [J].

Acar, M ;

Jafar-Nejad, H ;

Giagtzoglou, N ;

Yallampalli, S ;

David, G ;

He, Y ;

Delidakis, C ;

Bellen, HJ .

DEVELOPMENT, 2006, 133 (10) :1979-1989

[2] Regulators acting in combinatorial codes also act independently in single differentiating neurons [J].

Allan, DW ;

Park, D ;

St Pierre, SE ;

Taghert, PH ;

Thor, S .

NEURON, 2005, 45 (05) :689-700

[3] Specification of neuronal identities by feedforward combinatorial coding [J].

Baumgardt, Magnus ;

Miguel-Aliaga, Irene ;

Karlsson, Daniel ;

Ekman, Helen ;

Thor, Stefan .

PLOS BIOLOGY, 2007, 5 (02) :295-308

[4] Directing neurotransmitter identity of neurones derived from expanded adult neural stem cells [J].

Berninger, Benedikt ;

Guillemot, Francois ;

Goetz, Magdalena .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2007, 25 (09) :2581-2590

[5] Proneural genes and the specification of neural cell types [J].

Bertrand, N ;

Castro, DS ;

Guillemot, F .

NATURE REVIEWS NEUROSCIENCE, 2002, 3 (07) :517-530

[6]

Castanon I, 2001, DEVELOPMENT, V128, P3145

[7] Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif [J].

Castro, Diogo S. ;

Skowronska-Krawczyk, Dorota ;

Armant, Olivier ;

Donaldson, Ian J. ;

Parras, Carlos ;

Hunt, Charles ;

Critchley, James A. ;

Nguyen, Laurent ;

Gossler, Achim ;

Goettgens, Berthold ;

Matter, Jean-Marc ;

Guillemot, Francois .

DEVELOPMENTAL CELL, 2006, 11 (06) :831-844

[8] The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors [J].

Flora, Adriano ;

Garcia, Jesus J. ;

Thaller, Christina ;

Zoghbi, Huda Y. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (39) :15382-15387

[9] Neurogenin 2 has an essential role in development of the dentate gyrus [J].

Galichet, Christophe ;

Guillemot, Francois ;

Parras, Carlos M. .

DEVELOPMENT, 2008, 135 (11) :2031-2041

[10] Coupling of cell migration with neurogenesis by proneural bHLH factors [J].

Ge, WH ;

He, F ;

Kim, KJ ;

Blanchi, B ;

Coskun, V ;

Nguyen, L ;

Wu, XB ;

Zhao, J ;

Heng, JIT ;

Martinowich, K ;

Tao, JF ;

Wu, H ;

Castro, D ;

Sobeih, MM ;

Corfas, G ;

Gleeson, JG ;

Greenberg, ME ;

Guillemot, F ;

Sun, YE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (05) :1319-1324

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