Homonojirimycin isomers and glycosides from Aglaonema treubii

被引：66

作者：

Asano, N ^{[1
]}

Nishida, M ^{[1
]}

Kizu, H ^{[1
]}

Matsui, K ^{[1
]}

Watson, AA ^{[1
]}

Nash, RJ ^{[1
]}

机构：

[1] AFRC,INST GRASSLAND & ENVIRONM RES,ABERYSTWYTH SY23 3EB,DYFED,WALES

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 02期

关键词：

D O I：

10.1021/np960577n

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A 50% aqueous EtOH extract of Aglaonema treubii found to potently inhibit alpha-glucosidase was subjected to various ion-exchange column chromatographic steps to give 2(R),5(R)-bis-(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine (1), alpha-homonojirimycin (2), beta-homonojirimycin (3), alpha-homomannojirimycin (4), beta-homomannojirimycin (5), alpha-3,4-di-epi-homonojirimycin (6), 7-O-beta-D-glucopyranosyl-alpha-homonojirimycin (7), and 5-O-alpha-D-galactopyranosyl-alpha-homonojirimycin (8). Compounds 1 and 2 are known inhibitors of various alpha-glucosidases. Compounds 6 and 8 are new natural products. Compounds 3-5 and 7 have been chemically synthesized previously, but this is the first report of their natural occurrence.

引用

页码：98 / 101

页数：4

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