Oxytocin increases anxiety to unpredictable threat

被引:129
作者
Grillon, C. [1 ]
Krimsky, M. [1 ]
Charney, D. R. [1 ]
Vytal, K. [1 ]
Ernst, M. [2 ]
Cornwell, B. [1 ]
机构
[1] NIMH, Neurobiol Fear & Anxiety Sect, Intramural Res Program, Bethesda, MD 20892 USA
[2] NIMH, Emot Dev & Affect Neurosci Branch, Intramural Res Program, Bethesda, MD 20892 USA
关键词
FEAR;
D O I
10.1038/mp.2012.156
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:958 / 960
页数:4
相关论文
共 10 条
[1]   Neuroanatomical evidence for reciprocal regulation of the corticotrophin-releasing factor and oxytocin systems in the hypothalamus and the bed nucleus of the stria terminalis of the rat: Implications for balancing stress and affect [J].
Dabrowska, Joanna ;
Hazra, Rimi ;
Ahern, Todd H. ;
Guo, Ji-Dong ;
McDonald, Alexander J. ;
Mascagni, Franco ;
Muller, Jay F. ;
Young, Larry J. ;
Rainnie, Donald G. .
PSYCHONEUROENDOCRINOLOGY, 2011, 36 (09) :1312-1326
[2]   Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety [J].
Davis, Michael ;
Walker, David L. ;
Miles, Leigh ;
Grillon, Christian .
NEUROPSYCHOPHARMACOLOGY, 2010, 35 (01) :105-135
[3]   The Neuropeptide Oxytocin Regulates Parochial Altruism in Intergroup Conflict Among Humans [J].
De Dreu, Carsten K. W. ;
Greer, Lindred L. ;
Handgraaf, Michel J. J. ;
Shalvi, Shaul ;
Van Kleef, Gerben A. ;
Baas, Matthijs ;
Ten Velden, Femke S. ;
Van Dijk, Eric ;
Feith, Sander W. W. .
SCIENCE, 2010, 328 (5984) :1408-1411
[4]   Oxytocin and cooperation under conditions of uncertainty: The modulating role of incentives and social information [J].
Declerck, Carolyn H. ;
Boone, Christophe ;
Kiyonari, Toko .
HORMONES AND BEHAVIOR, 2010, 57 (03) :368-374
[5]   Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala [J].
Huber, D ;
Veinante, P ;
Stoop, R .
SCIENCE, 2005, 308 (5719) :245-248
[6]   Evoked Axonal Oxytocin Release in the Central Amygdala Attenuates Fear Response [J].
Knobloch, H. Sophie ;
Charlet, Alexandre ;
Hoffmann, Lena C. ;
Eliava, Marina ;
Khrulev, Sergey ;
Cetin, Ali H. ;
Osten, Pavel ;
Schwarz, Martin K. ;
Seeburg, Peter H. ;
Stoop, Ron ;
Grinevicht, Valery .
NEURON, 2012, 73 (03) :553-566
[7]   Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine [J].
Meyer-Lindenberg, Andreas ;
Domes, Gregor ;
Kirsch, Peter ;
Heinrichs, Markus .
NATURE REVIEWS NEUROSCIENCE, 2011, 12 (09) :524-538
[8]   Oxytocin Reduces Background Anxiety in a Fear-Potentiated Startle Paradigm [J].
Missig, Galen ;
Ayers, Luke W. ;
Schulkin, Jay ;
Rosen, Jeffrey B. .
NEUROPSYCHOPHARMACOLOGY, 2010, 35 (13) :2607-2616
[9]   Assessing fear and anxiety in humans using the threat of predictable and unpredictable aversive events (the NPU-threat test) [J].
Schmitz, Anja ;
Grillon, Christian .
NATURE PROTOCOLS, 2012, 7 (03) :527-532
[10]   Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala [J].
Viviani, Daniele ;
Charlet, Alexandre ;
van den Burg, Erwin ;
Robinet, Camille ;
Hurni, Nicolas ;
Abatis, Marios ;
Magara, Fulvio ;
Stoop, Ron .
SCIENCE, 2011, 333 (6038) :104-107