Hepatitis C virus and lipids in the era of direct acting antivirals (DAAs)

被引：24

作者：

Sheridan, David A. ^{[1
]}

Neely, R. Dermot G. ^{[2
]}

Bassendine, Margaret F. ^{[1
]}

机构：

[1] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[2] Royal Victoria Infirm, Dept Clin Biochem, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

来源：

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY | 2013年 / 37卷 / 01期

基金：

英国医学研究理事会;

关键词：

GENOTYPE; 1; INFECTION; DENSITY-LIPOPROTEIN RECEPTOR; TREATMENT-NAIVE PATIENTS; CORE PROTEIN; VIROLOGICAL RESPONSE; APOLIPOPROTEIN-E; IN-VITRO; NEUTRALIZING ANTIBODIES; POSITIVE LIPOPROTEINS; COMBINATION TREATMENT;

D O I：

10.1016/j.clinre.2012.07.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The six different HCV-genotypes have marked differences in response to therapy with pegylated interferon-alpha and ribavirin. The introduction of the direct acting antiviral (DAA) protease inhibitors, telaprevir and boceprevir in combination with pegylated interferon-alpha and ribavirin has become the new standard of care for genotype 1 infection. Several host factors associated with response to pegylated interferon-alpha and ribavirin are not as important in predicting response to triple therapy, and yet low-density lipoprotein cholesterol (LDLC) and statin use remain important associations of outcome with DAAs. This review focuses on the clinical associations between lipids and treatment response to interferon based antiviral treatments. We consider how understanding the interactions of HCV and host lipid metabolism remains relevant in the era of DAAs for genotype 1 infection and for treatment of non-genotype 1 chronic hepatitis C. (C) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：10 / 16

页数：7

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