Polymorphisms within the human tumor necrosis factor-alpha promoter region in human immunodeficiency virus type 1-seropositive persons

被引：37

作者：

Brinkman, BMN

Keet, IPM

Miedema, F

Verweij, CL

Klein, MR

机构：

[1] NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,DEPT CLIN VIROIMMUNOL,NL-1066 CX AMSTERDAM,NETHERLANDS

[2] UNIV LEIDEN HOSP,DEPT RHEUMATOL,NL-2300 RC LEIDEN,NETHERLANDS

[3] UNIV AMSTERDAM,EXPT & CLIN IMMUNOL LAB,AMSTERDAM,NETHERLANDS

[4] MUNICIPAL HLTH SERV,DEPT INFECT DIS,AMSTERDAM,NETHERLANDS

来源：

JOURNAL OF INFECTIOUS DISEASES | 1997年 / 175卷 / 01期

关键词：

D O I：

10.1093/infdis/175.1.188

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The question is addressed whether particular tumor necrosis factor-alpha (TNF-alpha) polymorphisms are associated with clinical course and outcome of human immunodeficiency virus type 1 (HIV-1) infection. The distribution of four TNF-alpha guanine (G) to adenosine (A) transition polymorphisms at positions -376, -308, -238, and -163 of the 5' promoter region of the TNF-alpha gene was studied in a nested case-control study among HIV-1-seropositive participants of the Amsterdam Cohort. None of the polymorphisms was significantly associated with long-term asymptomatic survival after HIV-1 infection compared with progression to clinical AIDS. Moreover, specific AIDS-defining illnesses or biologic phenotype of the HIV-1 virus were not associated with TNF-alpha alleles. The results of this study do not point toward a role for known TNF-alpha G to A transition polymorphisms in the clinical course of HIV-1 infection.

引用

页码：188 / 190

页数：3

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