Exploring the Link between Serum Phosphate Levels and Low Muscle Strength, Dynapenia, and Sarcopenia

被引:42
作者
Chen, Yuan-Yuei [1 ,2 ,3 ]
Kao, Tung-Wei [2 ,3 ,5 ,6 ]
Chou, Cheng-Wai [2 ,3 ]
Wu, Chen-Jung [2 ,3 ,4 ]
Yang, Hui-Fang [2 ,3 ,5 ]
Lai, Ching-Huang [7 ]
Wu, Li-Wei [2 ,3 ,5 ]
Chen, Wei-Liang [2 ,3 ,5 ]
机构
[1] Triserv Gen Hosp, Natl Def Med Ctr, Sch Med, Dept Internal Med,Songshan Branch, Taipei, Taiwan
[2] Triserv Gen Hosp, Dept Family & Community Med, Div Family Med, Taipei, Taiwan
[3] Natl Def Med Ctr, Sch Med, Taipei, Taiwan
[4] Taoyuan Armed Forces Gen Hosp, Dept Community Med, Div Family Med, Taoyuan, Taiwan
[5] Triserv Gen Hosp, Dept Family & Community Med, Div Geriatr Med, Taipei, Taiwan
[6] Natl Taiwan Univ, Coll Med, Grad Inst Clin Med, Taipei, Taiwan
[7] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan
来源
SCIENTIFIC REPORTS | 2018年 / 8卷
关键词
SKELETAL-MUSCLE; VASCULAR CALCIFICATION; DIETARY PHOSPHATE; FORCE GENERATION; PHOSPHORUS; MORTALITY; HYPOPHOSPHATEMIA; ASSOCIATION; CALCIUM; HEALTH;
D O I
10.1038/s41598-018-21784-1
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Emerging evidences addressed an association between phosphate and muscle function. Because little attention was focused on this issue, the objective of our study was to explore the relationship of phosphate with muscle strength, dynapenia, and sarcopenia. From the National Health and Nutrition Examination Survey, a total of 7421 participants aged 20 years or older were included in our study with comprehensive examinations included anthropometric parameters, strength of the quadriceps muscle, and appendicular lean masses. Within the normal range of serum phosphate, we used quartile-based analyses to determine the potential relationships of serum phosphate with dynapenia, and sarcopenia through multivariate regression models. After adjusting for the pertinent variables, an inverse association between the serum phosphate quartiles and muscle strength was observed and the linear association was stronger than other anthropometric parameters. Notably, the significant association between phosphate and muscle strength was existed in >65 years old age group, not in 20-65 years old. The higher quartiles of phosphate had higher likelihood for predicting the presence of dynapenia rather than sarcopenia in entire population. Our study highlighted that higher quartiles of phosphate had significant association with lower muscle strength and higher risks for predicting the presence of dynapenia.
引用
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页数:9
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