The Double-Edged Sword How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer

被引：34

作者：

Wang, Hao-fan ^{[1
]}

Wang, Sha-sha ^{[1
]}

Tang, Ya-Jie ^{[2
]}

Chen, Yu ^{[3
]}

Zheng, Min ^{[4
]}

Tang, Ya-ling ^{[3
]}

Liang, Xin-hua ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp Stomatol, Dept Oral & Maxillofacial Surg, Natl Clin Res Ctr Oral Dis,State Key Lab Oral Dis, Chengdu, Sichuan, Peoples R China

[2] Hubei Univ Technol, Hubei Prov Cooperat Innovat Ctr Ind Fermentat, Hubei Key Lab Ind Microbiol, Minist Educ,Key Lab Fermentat Engn, Wuhan, Hubei, Peoples R China

[3] Sichuan Univ, West China Hosp Stomat, Natl Clin Res Ctr Oral Dis, Dept Oral Pathol,State Key Lab Oral Dis, Chengdu, Sichuan, Peoples R China

[4] Wenzhou Med Univ, Zhoushan Hosp, Dept Stomatobgy, Zhoushan, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷

基金：

中国国家自然科学基金;

关键词：

human papilloma virus (HPV); head and neck squamous cell carcinoma (HNSCC); immune escape; immune responses; immunotherapy; SQUAMOUS-CELL CARCINOMA; TUMOR-INFILTRATING LYMPHOCYTES; HPV-ASSOCIATED HEAD; REGULATORY T-CELLS; LANGERHANS CELLS; CERVICAL-CANCER; PD-L1; EXPRESSION; POSITIVE HEAD; E5; PROTEIN; E7;

D O I：

10.3389/fimmu.2019.00653

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Patients with human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) have remarkably better prognosis, which differs from HPV-negative oropharyngeal squamous cell carcinoma (OPSCC) with respect to clinical, genomic, molecular, and immunological aspects, especially having the characteristics of high levels of immune cell infiltration and high degrees of immunosuppression. This review will summarize immune evasion mechanisms in HPV-positive HNSCC, analyze the host various immune responses to HPV and abundant numbers of infiltrating immune cell, and discuss the differences between HPV-positive HNSCC with cervical cancer. A deeper understanding of the immune landscape will help new concepts to emerge in immune-checkpoint oncology, which might be a valuable add-on to established concepts.

引用

页数：12

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