Immunological properties of oxygen-transport proteins: hemoglobin, hemocyanin and hemerythrin

被引：111

作者：

Coates, Christopher J. ^{[1
]}

Decker, Heinz ^{[2
]}

机构：

[1] Swansea Univ, Coll Sci, Dept Biosci, Singleton Pk, Swansea SA2 8PP, W Glam, Wales

[2] Johannes Gutenberg Univ Mainz, Inst Mol Biophys, Jakob Welder Weg 28, D-55128 Mainz, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2017年 / 74卷 / 02期

关键词：

Antimicrobial peptides; Innate immunity; Myoglobin; Phenoloxidase; Erythrocytes; Enzyme promiscuity; Metabolism; Redox; INDUCED PHENOLOXIDASE-ACTIVITY; RAPANA-THOMASIANA HEMOCYANIN; CLAM TEGILLARCA-GRANOSA; BOVINE ALPHA-HEMOGLOBIN; INNATE IMMUNE-RESPONSE; ANTIMICROBIAL PEPTIDE; ANTIBACTERIAL PEPTIDE; EXTRACELLULAR HEMOGLOBIN; EXPRESSION ANALYSIS; MYCOBACTERIUM-TUBERCULOSIS;

D O I：

10.1007/s00018-016-2326-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is now well documented that peptides with enhanced or alternative functionality (termed cryptides) can be liberated from larger, and sometimes inactive, proteins. A primary example of this phenomenon is the oxygen-transport protein hemoglobin. Aside from respiration, hemoglobin and hemoglobin-derived peptides have been associated with immune modulation, hematopoiesis, signal transduction and microbicidal activities in metazoans. Likewise, the functional equivalents to hemoglobin in invertebrates, namely hemocyanin and hemerythrin, act as potent immune effectors under certain physiological conditions. The purpose of this review is to evaluate the true extent of oxygen-transport protein dynamics in innate immunity, and to impress upon the reader the multi-functionality of these ancient proteins on the basis of their structures. In this context, erythrocyte-pathogen antibiosis and the immune competences of various erythroid cells are compared across diverse taxa.

引用

页码：293 / 317

页数：25

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