Protective effect of L-citrulline against ethanol-induced gastric ulcer in rats

被引：79

作者：

Liu, Yi ^{[1
]}

Tian, Xia ^{[1
]}

Gou, Lingshan ^{[1
]}

Fu, Xiaobin ^{[1
]}

Li, Sai ^{[1
]}

Lan, Nuo ^{[1
]}

Yin, Xiaoxing ^{[1
]}

机构：

[1] Xuzhou Med Coll, Sch Pharm, Dept Pharm, Xuzhou 221002, Jiangsu, Peoples R China

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2012年 / 34卷 / 02期

关键词：

L-Citrulline; Ethanol; Gastric ulcer; Rat; COLD-RESTRAINT STRESS; NITRIC-OXIDE; MUCOSAL LESIONS; LIPID-PEROXIDATION; NEUTROPHIL INFILTRATION; OXIDATIVE STRESS; L-ARGININE; INFLAMMATION; SUPPLEMENTATION; CYTOPROTECTION;

D O I：

10.1016/j.etap.2012.04.009

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

We examined the protective effect of L-citrulline on ethanol-induced gastric ulcer in rats. Administration of L-citrulline at doses of 300, 600 and 900 mg/kg body weight prior to ethanol ingestion protected the stomach from ulceration. The gastric lesions were significantly attenuated by all doses of L-citrulline as compared to the ethanol group. Pre-treatment with L-citrulline prevented the oxidative damage and the decrease of nitric oxide content as well as the increase of the myeloperoxidase activity. Consequently, significant changes observed included the attenuation in the elevation in total nitric oxide synthase activity and inducible nitric oxide synthase activity as well as the decrease in constitutive nitric oxide synthase activity in the gastric mucosa induced by ethanol. Analysis of serum cytokines of ethanol-induced rats showed a moderate decrease in interleukin-10 with considerable increase of interleukin-6 while L-citrulline inhibited the acute alteration of cytokines. These results suggested the gastroprotective effect of L-citrulline. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：280 / 287

页数：8

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