Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats:: VMAT2 binding is sensitive to changes in vesicular dopamine concentration

被引：36

作者：

Tong, Junchao ^{[1
]}

Wilson, Alan A. ^{[2
]}

Boileau, Isabelle ^{[1
]}

Houle, Sylvain ^{[2
]}

Kish, Stephen J. ^{[1
]}

机构：

[1] Ctr Addict & Mental Hlth, Human Neurochem Pathol Lab, Toronto, ON M5T 1R8, Canada

[2] Ctr Addict & Mental Hlth, Vivian M Rakoff PET Ctr, Toronto, ON M5T 1R8, Canada

来源：

SYNAPSE | 2008年 / 62卷 / 11期

关键词：

dihydrotetrabenazine; vesicular monoamine transporter; positron emission tomography;

D O I：

10.1002/syn.20573

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Binding of (+)-[(11)C]DTBZ (dihydrotetrabenazine) to the striatal vesicular monoamine transporter (VMAT2) is widely considered to be a stable marker of dopamine neurone integrity. However, we now find that specific binding of a tracer dose of (+)-[(11)C]DTBZ is modestly increased in rat striatum following dopamine depletion with alpha-methyl p-tyrosine (alpha-MPT, +14%) or d-amphetamine (d-AMPH, 20 mg/kg, +12%) and decreased following dopamine elevation with gamma-hydroxybutyrate (GHB, -16%) or levodopa (-20%). We suggest that in vivo (+)-[(11)C]DTBZ binding in imaging studies is subject to competition by vesicular dopamine and, in this respect, is not a "stable" dopamine biomarker as is generally assumed.

引用

页码：873 / 876

页数：4

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