New Diagnostics for Childhood Tuberculosis

被引：44

作者：

Chiang, Silvia S. ^{[1
,3
]}

Swanson, Douglas S. ^{[2
]}

Starke, Jeffrey R. ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Pediat, Infect Dis Sect, Houston, TX 77030 USA

[2] Univ Missouri, Sch Med, Dept Pediat, Div Infect Dis, Kansas City, MO 64108 USA

[3] Harvard Univ, Sch Med, Dept Global Hlth & Social Med, Boston, MA 02115 USA

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2015年 / 29卷 / 03期

关键词：

Childhood tuberculosis; Diagnosis; Drug susceptibility testing; Interferon-gamma release assay; Microscopic-observation drug-susceptibility assay; Xpert MTB/RIF; Nitrate reductase assay; Line probe assays; MULTIDRUG-RESISTANT TUBERCULOSIS; GAMMA RELEASE ASSAYS; AFRICAN POUCHED RATS; ELECTRONIC-NOSE TECHNOLOGY; DRUG SUSCEPTIBILITY ASSAY; NITRATE REDUCTASE ASSAY; FINE-NEEDLE-ASPIRATION; T-CELL ASSAYS; MYCOBACTERIUM-TUBERCULOSIS; PULMONARY TUBERCULOSIS;

D O I：

10.1016/j.idc.2015.05.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The challenge of diagnosing childhood tuberculosis (TB) results from its paucibacillary nature and the difficulties of sputum collection in children. Mycobacterial culture, the diagnostic gold standard, provides microbiological confirmation in only 30% to 40% of childhood pulmonary TB cases and takes up to 6 weeks to result. Conventional drug susceptibility testing requires an additional 2 to 4 weeks after culture confirmation. In response to the low sensitivity and long wait time of the traditional diagnostic approach, many new assays have been developed. These new tools have shortened time to result; however, none of them offer greater sensitivity than culture.

引用

页码：477 / +

页数：27

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