Serum CA19-9 Level Associated with Metabolic Control and Pancreatic Beta Cell Function in Diabetic Patients

被引：29

作者：

Yu, Haoyong ^{[1
,2
]}

Li, Ruixia ^{[1
,3
]}

Zhang, Lei ^{[1
]}

Chen, Haibing ^{[1
]}

Bao, Yuqian ^{[1
]}

Jia, Weiping ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Endocrinol & Metab, Shanghai Diabet Inst,Shanghai Clin Ctr Diabet,Sha, Shanghai 200233, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200233, Peoples R China

[3] Soochow Univ, Dept Med, Suzhou 215006, Peoples R China

来源：

EXPERIMENTAL DIABETES RESEARCH | 2012年

基金：

中国国家自然科学基金;

关键词：

CA-19-9; LEVELS; MELLITUS; CHOLESTEROL;

D O I：

10.1155/2012/745189

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

CA19-9 is a tumor-associated antigen. It is also a marker of pancreatic tissue damage that might be caused by diabetes. Long-term poor glycemic control may lead to pancreatic beta cell dysfunction which is reflected by elevated serum CA19-9 level. Intracellular cholesterol accumulation leads to islet dysfunction and impaired insulin secretion which provide a new lipotoxic model. This study firstly found total cholesterol was one of the independent contributors to CA19-9. Elevated serum CA19-9 level in diabetic patients may indicate further investigations of glycemic control, pancreatic beta cell function, and total cholesterol level.

引用

页数：5

共 15 条

[1]

ARAKAWA Y, 1985, JPN J MED, V24, P121

[2]

BENHAMOU PY, 1991, DIABETES METAB, V17, P39

[3]

BLUMENTHAL HT, 1963, ARCH SURG-CHICAGO, V87, P844

[4] CA 19-9 Level in Patients With Type 2 Diabetes Mellitus and Its Relation to the Metabolic Control and Microvascular Complications [J].

Gul, Kamile ;

Nas, Sevinc ;

Ozdemir, Didem ;

Gumus, Mehmet ;

Ersoy, Reyhan ;

Cakir, Bekir .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2011, 341 (01) :28-32

[5] Direct effect of cholesterol on insulin secretion -: A novel mechanism for pancreatic β-cell dysfunction [J].

Hao, Mingming ;

Head, W. Steven ;

Gunawardana, Subhadra C. ;

Hasty, Alyssa H. ;

Piston, David W. .

DIABETES, 2007, 56 (09) :2328-2338

[6] Exocrine Pancreatic Insufficiency in Diabetes Mellitus: A Complication of Diabetic Neuropathy or a Different Type of Diabetes? [J].

Hardt, Philip D. ;

Ewald, Nils .

EXPERIMENTAL DIABETES RESEARCH, 2011,

[7] Cholesterol accumulation and diabetes in pancreatic β-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity [J].

Ishikawa, Mayumi ;

Iwasaki, Yuko ;

Yatoh, Shigeru ;

Kato, Toyonori ;

Kumadaki, Shin ;

Inoue, Noriyuki ;

Yamamoto, Takashi ;

Matsuzaka, Takashi ;

Nakagawa, Yoshimi ;

Yahagi, Naoya ;

Kobayashi, Kazuto ;

Takahashi, Akimitsu ;

Yamada, Nobuhiro ;

Shimano, Hitoshi .

JOURNAL OF LIPID RESEARCH, 2008, 49 (12) :2524-2534

[8] Cholesterol metabolism and beta-cell function [J].

Langhi, Cedric ;

Cariou, Bertrand .

M S-MEDECINE SCIENCES, 2010, 26 (04) :385-390

[9] ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer [J].

Locker, Gershon Y. ;

Hamilton, Stanley ;

Harris, Jules ;

Jessup, John M. ;

Kemeny, Nancy ;

Macdonald, John S. ;

Somerfield, Mark R. ;

Hayes, Daniel F. ;

Bast, Robert C., Jr. .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (33) :5313-5327

[10] ELEVATION OF TUMOR-ASSOCIATED CARBOHYDRATE ANTIGENS IN PATIENTS WITH DIFFUSE PANBRONCHIOLITIS [J].

MUKAE, H ;

HIROTA, M ;

KOHNO, S ;

KOMORI, K ;

FUKUSHIMA, K ;

HIRATANI, K ;

KADOTA, JI ;

HARA, K .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 148 (03) :744-751

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