Ethanol Lock Therapy in Pediatric Hematology and Oncology

被引：39
作者：
Wolf, Joshua [1 ,2 ,3 ]
Shenep, Jerry L. [1 ,2 ]
Clifford, Vanessa [3 ,4 ,5 ]
Curtis, Nigel [3 ,4 ,5 ]
Flynn, Patricia M. [1 ,2 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA
[2] Univ Tennessee, Ctr Hlth Sci, Dept Pediat, Memphis, TN 38163 USA
[3] Univ Melbourne, Dept Paediat, Parkville, Vic 3052, Australia
[4] Royal Childrens Hosp Melbourne, Infect Dis Unit, Parkville, Vic, Australia
[5] Royal Childrens Hosp Melbourne, Murdoch Childrens Res Inst, Parkville, Vic, Australia
来源：
PEDIATRIC BLOOD & CANCER | 2013年 / 60卷 / 01期
关键词：
bacteremia; catheterization; central venous; catheter-related infections; child; ethanol; hematology; neoplasms; BLOOD-STREAM INFECTIONS; CATHETER-RELATED INFECTIONS; CENTRAL VENOUS CATHETERS; PARENTERAL-NUTRITION PATIENTS; INTENSIVE-CARE-UNIT; MECHANICAL-PROPERTIES; INTESTINAL FAILURE; HEMODIALYSIS CATHETERS; ANTIBIOTIC-RESISTANCE; TAUROLIDINE-CITRATE;
D O I：
10.1002/pbc.24249
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Central venous catheters are essential for treatment of cancer and hematologic disorders in children. Central line-associated bloodstream infection (CLABSI) is the most common important complication and can lead to serious sequelae. Conventional antibiotic treatment is often unsuccessful. Ethanol lock therapy (ELT) has been shown to prevent CLABSI in various patient groups and might also be beneficial as adjunctive treatment for active infection. Efficacy and safety have not been adequately studied in the pediatric hematology/oncology population. Catheter occlusion and intraluminal clots have been reported. Routine use of ELT should not be recommended in this population until more data are available. Pediatr Blood Cancer 2013; 60: 18-25. (C) 2012 Wiley Periodicals, Inc.
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收藏
页码：18 / 25
页数：8
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