CMU Array: A 3D nanoprinted, fully customizable high-density microelectrode array platform

被引：42

作者：

Saleh, Mohammad Sadeq ^{[1
,7
]}

Ritchie, Sandra M. ^{[1
]}

Nicholas, Mark A. ^{[2
,3
,4
]}

Gordon, Hailey L. ^{[2
]}

Hu, Chunshan ^{[1
]}

Jahan, Sanjida ^{[1
]}

Yuan, Bin ^{[1
]}

Bezbaruah, Rriddhiman ^{[1
]}

Reddy, Jay W. ^{[5
]}

Ahmed, Zabir ^{[5
]}

Chamanzar, Maysamreza ^{[5
]}

Yttri, Eric A. ^{[2
,6
]}

Panat, Rahul P. ^{[1
,6
]}

机构：

[1] Carnegie Mellon Univ, Dept Mech Engn, Pittsburgh, PA 15213 USA

[2] Carnegie Mellon Univ, Dept Biol Sci, Pittsburgh, PA 15213 USA

[3] Carnegie Mellon Univ, Centerfor Neural Basis Cognit, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Pittsburgh, PA 15213 USA

[5] Carnegie Mellon Univ, Dept Elect & Comp Engn, Pittsburgh, PA 15213 USA

[6] Carnegie Mellon Univ, Carnegie Mellon Neurosci Inst, Pittsburgh, PA 15213 USA

[7] Princeton Univ, Dept Mech Engn, Princeton, NJ 08544 USA

来源：

SCIENCE ADVANCES | 2022年 / 8卷 / 40期

基金：

美国安德鲁·梅隆基金会;

关键词：

ELECTRODE ARRAY; SCALE;

D O I：

10.1126/sciadv.abj4853

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Microelectrode arrays provide the means to record electrophysiological activity critical to brain research. Despite its fundamental role, there are no means to customize electrode layouts to address specific experimental or clinical needs. Moreover, current electrodes demonstrate substantial limitations in coverage, fragility, and expense. Using a 3D nanoparticle printing approach that overcomes these limitations, we demonstrate the first in vivo recordings from electrodes that make use of the flexibility of the 3D printing process. The customizable and physically robust 3D multi-electrode devices feature high electrode densities (2600 channels/cm2 of footprint) with minimal gross tissue damage and excellent signal-to-noise ratio. This fabrication methodology also allows flexible reconfiguration consisting of different individual shank lengths and layouts, with low overall channel impedances. This is achieved, in part, via custom 3D printed multilayer circuit boards, a fabrication advancement itself that can support several biomedical device possibilities. This effective device design enables both targeted and large-scale recording of electrical signals throughout the brain.

引用

页数：16