Genetic variants of MnSOD and GPX1 and susceptibility to bladder cancer in a Turkish population

被引：27

作者：

Kucukgergin, Canan ^{[1
]}

Sanli, Oner ^{[2
]}

Amasyali, Akin S. ^{[3
]}

Tefik, Tzevat ^{[2
]}

Seckin, Sule ^{[1
]}

机构：

[1] Istanbul Univ, Dept Biochem, Istanbul Fac Med, TR-34093 Istanbul, Turkey

[2] Istanbul Univ, Dept Urol, Istanbul Fac Med, TR-34093 Istanbul, Turkey

[3] Istanbul Teaching & Res Hosp, Dept Urol, TR-34098 Istanbul, Turkey

来源：

MEDICAL ONCOLOGY | 2012年 / 29卷 / 03期

关键词：

Manganese superoxide dismutase; Glutathione peroxidase 1; Single nucleotide polymorphism; Polymerase chain reaction-restriction fragment length polymerase analysis; Bladder cancer; Turkish population; MANGANESE SUPEROXIDE-DISMUTASE; CYTOSOLIC GLUTATHIONE-PEROXIDASE; BREAST-CANCER; LUNG-CANCER; PRO198LEU POLYMORPHISM; OXIDATIVE STRESS; ALCOHOL-CONSUMPTION; PROSTATE-CANCER; NO ASSOCIATION; I GENE;

D O I：

10.1007/s12032-011-0057-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study was conducted to investigate the association of genetic polymorphisms in the MnSOD and GPX1 genes with the risk and invasiveness of bladder cancer in a Turkish population. This prospectively designed study enrolled 157 patients with bladder cancer (mean age 63.2 +/- 10.86 years) and 224 healthy controls (mean age 61.7 +/- 8.39 years). Genotyping of the MnSOD Ala-9Val and GPX1 Pro198Leu polymorphisms was carried out by PCR-RFLP. No significant difference was found in MnSOD genotype distributions between the controls and the bladder cancer patients. However, the Leu/Leu genotype of GPX1 was associated with a significantly higher risk of bladder cancer than the Pro/Pro genotype. When stratified according to tumor stage, the Leu/Leu genotype of GPX1 was more frequently observed in bladder cancer patients with high-stage tumors than those with low-stage tumors. Additionally, patients carrying both Ala/Ala of MnSOD and Leu/Leu of GPX1 had the highest risk of developing bladder cancer. In conclusion, the present study indicates that the GPX1 Pro198Leu polymorphism may be associated with the risk and development of invasive bladder cancer. In addition, the combination of the MnSOD Ala/Ala and GPX1 Leu/Leu genotypes may have a synergistic effect on disease risk.

引用

页码：1928 / 1934

页数：7

共 44 条

[1] Single-nucleotide polymorphisms within the antioxidant defence system and associations with aggressive prostate cancer [J].

Abe, Miyako ;

Xie, Wanling ;

Regan, Meredith M. ;

King, Irena B. ;

Stampfer, Meir J. ;

Kantoff, Philip W. ;

Oh, William K. ;

Chan, June M. .

BJU INTERNATIONAL, 2011, 107 (01) :126-134

[2] No association between glutathione peroxidase Pro198Leu polymorphism and breast cancer risk [J].

Ahn, J ;

Gammon, MD ;

Santella, RM ;

Gaudet, MM ;

Britton, JA ;

Teitelbaum, SL ;

Terry, MB ;

Neugut, AI ;

Ambrosone, CB .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2005, 14 (10) :2459-2461

[3]

Ambrosone CB, 1999, CANCER RES, V59, P602

[4] Glutathione peroxidase 1 (GPX1) genetic polymorphism, erythrocyte GPX activity, and prostate cancer risk [J].

Arsova-Sarafinovska, Zorica ;

Matevska, Nadica ;

Eken, Ayse ;

Petrovski, Daniel ;

Banev, Saso ;

Dzikova, Sonja ;

Georgiev, Vladimir ;

Sikole, Aleksandar ;

Erdem, Onur ;

Sayal, Ahmet ;

Aydin, Ahmet ;

Dimovski, Aleksandar J. .

INTERNATIONAL UROLOGY AND NEPHROLOGY, 2009, 41 (01) :63-70

[5]

Arthur JR, 2000, CELL MOL LIFE SCI, V57, P1825

[6] Altered antioxidant status and lipid peroxidation in Indian patients with urothelial bladder carcinoma [J].

Badjatia, Nitika ;

Satyam, Abhigyan ;

Singh, Prabhjot ;

Seth, Amlesh ;

Sharma, Alpana .

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2010, 28 (04) :360-367

[7] MITOCHONDRIAL MUTATIONS MAY INCREASE OXIDATIVE STRESS - IMPLICATIONS FOR CARCINOGENESIS AND AGING [J].

BANDY, B ;

DAVISON, AJ .

FREE RADICAL BIOLOGY AND MEDICINE, 1990, 8 (06) :523-539

[8] Role of the 3' untranslated region in the regulation of cytosolic glutathione peroxidase and phosphlipid-hydroperoxide glutathione peroxidase gene expression by selenium supply [J].

Bermano, G ;

Arthur, JR ;

Hesketh, JE .

BIOCHEMICAL JOURNAL, 1996, 320 :891-895

[9]

Bica Claudia Giuliano, 2007, J. Bras. Patol. Med. Lab., V43, P219, DOI 10.1590/S1676-24442007000300012

[10] Hypoxia and oxidative stress in breast cancer - Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer [J].

Brown, NS ;

Bicknell, R .

BREAST CANCER RESEARCH, 2001, 3 (05) :323-327

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