Effect of bone marrow mesenchymal stem cells on experimental pulmonary arterial hypertension

被引：28
|
作者：
Zhang, Zhao-Hua [2 ]
Lu, Yan [3 ]
Luan, Yun [4 ]
Zhao, Jing-Jie [1 ]
机构：
[1] Shandong Univ, Hosp 2, Clin Mol Biol Lab, Jinan 250033, Peoples R China
[2] Shandong Univ, Hosp 2, Dept Pediat, Jinan 250033, Peoples R China
[3] Beijing Univ Aeronaut & Astronaut, Dept Pathol, Beijing 100083, Peoples R China
[4] Shandong Univ, Hosp 2, Cent Res Lab, Jinan 250033, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2012年 / 4卷 / 05期
关键词：
bone marrow mesenchymal stem cells; pulmonary arterial hypertension; pulmonary vascular wall; TRANSMYOCARDIAL DEGRADABLE STENT; GROWTH-FACTOR; ANGIOGENESIS; ISCHEMIA; HYPOXIA; MODEL; RATS;
D O I：
10.3892/etm.2012.691
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The aim of the present study was to investigate the effect of bone marrow mesenchymal stem cell (BMSC) transplantation on lung and heart damage in a rat model of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). The animals were randomly divided into 3 groups: control, PAH and BMSC implantation groups. Structural changes in the pulmonary vascular wall, such as the pulmonary artery lumen area (VA) and vascular area (TAA) were measured by hematoxyl in and eosin (H&E) staining, and the hemodynamics were detected by echocardiography. Two weeks post-operation, our results demonstrated that sublingual vein injection of BMSCs significantly attenuated the pulmonary vascular structural and hemodynamic changes caused by pulmonary arterial hypertension. The mechanism may be executed via paracrine effects.
引用
收藏
页码：839 / 843
页数：5
相关论文
共 50 条
  • [41] Reversible course of pulmonary arterial hypertension related to bone marrow transplantation
    Alisa Limsuwan
    Samart Pakakasama
    Suradej Hongeng
    Heart and Vessels, 2011, 26 : 557 - 561
  • [42] Reversible course of pulmonary arterial hypertension related to bone marrow transplantation
    Limsuwan, Alisa
    Pakakasama, Samart
    Hongeng, Suradej
    HEART AND VESSELS, 2011, 26 (05) : 557 - 561
  • [43] Comparative analysis on the anti-inflammatory/immune effect of mesenchymal stem cell therapy for the treatment of pulmonary arterial hypertension
    Oh, Seyeon
    Jang, Albert Y.
    Chae, Sehyun
    Choi, Seungbum
    Moon, Jeongsik
    Kim, Minsu
    Spiekerkoetter, Edda
    Zamanian, Roham T.
    Yang, Phillip C.
    Hwang, Daehee
    Byun, Kyunghee
    Chung, Wook-Jin
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [44] Bone marrow mesenchymal stem cells alleviate the formation of pathological scars in rats
    Xu, Ji-Hua
    Xu, Sheng-Quan
    Ding, Shi-Li
    Yang, Hu
    Huang, Xin
    Shi, Hai-Fei
    REGENERATIVE THERAPY, 2022, 20 : 86 - 94
  • [45] Contribution of bone marrow mesenchymal stem cells to porcine hepatocyte culture in vitro
    Gu, Jinyang
    Shi, Xiaolei
    Chu, Xuehui
    Zhang, Yue
    Ding, Yitao
    BIOCHEMISTRY AND CELL BIOLOGY, 2009, 87 (04) : 595 - 604
  • [46] Effects of bone marrow mesenchymal stem cells in a rat model of myocardial infarction
    Wang, Tong
    Sun, Shijie
    Wan, Zhi
    Weil, Max Harry
    Tang, Wanchun
    RESUSCITATION, 2012, 83 (11) : 1391 - 1396
  • [47] Multiple myeloma and bone marrow mesenchymal stem cells' crosstalk: Effect on translation initiation
    Attar-Schneider, Oshrat
    Zismanov, Victoria
    Dabbah, Mahmoud
    Tartakover-Matalon, Shelly
    Drucker, Liat
    Lishner, Michael
    MOLECULAR CARCINOGENESIS, 2016, 55 (09) : 1343 - 1354
  • [48] The Effect of Metformin on the Differentiation of Bone Marrow Mesenchymal Stem Cells into Chondrocytes with a Hypertrophic Phenotype
    Zhu, Zhehui
    Meng, Weidong
    Liu, Shizhang
    JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 2022, 12 (12) : 2387 - 2394
  • [49] Effect of autologous bone marrow derived mesenchymal stem cells in treatment of rheumatoid arthritis
    Elbasha, Yara I.
    Mesbah, Noha M.
    Abdel-Hamed, Asmaa R.
    Abo-Elmatty, Dina M.
    Bakry, Sayed
    Mansour, Ahmed M.
    Elbeialy, Adel A.
    TRANSPLANT IMMUNOLOGY, 2023, 80
  • [50] Neurotrophic effect of bone marrow mesenchymal stem cells for erectile dysfunction in diabetic rats
    Sun, C.
    Lin, H.
    Yu, W.
    Li, X.
    Chen, Y.
    Qiu, X.
    Wang, R.
    Dai, Y.
    INTERNATIONAL JOURNAL OF ANDROLOGY, 2012, 35 (04): : 601 - 607
12345