Effect of bone marrow mesenchymal stem cells on experimental pulmonary arterial hypertension

被引：28
|
作者：
Zhang, Zhao-Hua [2 ]
Lu, Yan [3 ]
Luan, Yun [4 ]
Zhao, Jing-Jie [1 ]
机构：
[1] Shandong Univ, Hosp 2, Clin Mol Biol Lab, Jinan 250033, Peoples R China
[2] Shandong Univ, Hosp 2, Dept Pediat, Jinan 250033, Peoples R China
[3] Beijing Univ Aeronaut & Astronaut, Dept Pathol, Beijing 100083, Peoples R China
[4] Shandong Univ, Hosp 2, Cent Res Lab, Jinan 250033, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2012年 / 4卷 / 05期
关键词：
bone marrow mesenchymal stem cells; pulmonary arterial hypertension; pulmonary vascular wall; TRANSMYOCARDIAL DEGRADABLE STENT; GROWTH-FACTOR; ANGIOGENESIS; ISCHEMIA; HYPOXIA; MODEL; RATS;
D O I：
10.3892/etm.2012.691
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The aim of the present study was to investigate the effect of bone marrow mesenchymal stem cell (BMSC) transplantation on lung and heart damage in a rat model of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). The animals were randomly divided into 3 groups: control, PAH and BMSC implantation groups. Structural changes in the pulmonary vascular wall, such as the pulmonary artery lumen area (VA) and vascular area (TAA) were measured by hematoxyl in and eosin (H&E) staining, and the hemodynamics were detected by echocardiography. Two weeks post-operation, our results demonstrated that sublingual vein injection of BMSCs significantly attenuated the pulmonary vascular structural and hemodynamic changes caused by pulmonary arterial hypertension. The mechanism may be executed via paracrine effects.
引用
收藏
页码：839 / 843
页数：5
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