Multicatalytic Synthesis of α-Pyrrolidinyl Ketones via a Tandem Palladium(II)/Indium(III)-Catalyzed Aminochlorocarbonylation/Friedel-Crafts Acylation Reaction

被引：121

作者：

Cernak, Tim A. ^{[1
]}

Lambert, Tristan H. ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 09期

基金：

美国国家科学基金会;

关键词：

INTRAMOLECULAR ALKOXYPALLADATION CARBONYLATION; ALKOXY-CARBONYLATION; INDIUM TRICHLORIDE; ALKYLATION; CATALYSIS; TRANSFORMATIONS; SUBSTITUTION; HETEROCYCLES; CYCLIZATION; STRATEGIES;

D O I：

10.1021/ja809897f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An oxidative carbonylation reaction that generates acid chloride functionality has been developed. Furthermore, this aminochlorocarbonylation reaction has been merged with a catalytic Friedel-Crafts acylation to produce a highly efficient tandem multicatalytic synthesis of pyrrolidinyl ketones. Significant variation of the aromatic nucleophile and substrate are shown. Two examples of incorporation of this method in triple-catalytic sequences are also demonstrated.

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页码：3124 / +

页数：3

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