Complete Sequence of a KPC-Producing IncN Multidrug-Resistant Plasmid from an Epidemic Escherichia coli Sequence Type 131 Strain in China

被引：58

作者：

Chen, Liang ^{[1
]}

Hu, Hongyan ^{[2
]}

Chavda, Kalyan D. ^{[1
]}

Zhao, Shulong ^{[3
]}

Liu, Renkun ^{[3
]}

Liang, Hui ^{[2
]}

Zhang, Wei ^{[2
]}

Wang, Xiumei ^{[2
]}

Jacobs, Michael R. ^{[4
,5
]}

Bonomo, Robert A. ^{[6
,7
,8
,9
,10
]}

Kreiswirth, Barry N. ^{[1
]}

机构：

[1] Rutgers State Univ, NJMS, TB Ctr, Publ Hlth Res Inst, Newark, NJ 07102 USA

[2] Gen Hosp Chinese Peoples Armed Police Forces, Dept Lab Med, Beijing, Peoples R China

[3] Xuzhou Med Coll, Grad Sch, Xuzhou, Jiangsu, Peoples R China

[4] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

[5] Univ Hosp Case Med Ctr, Cleveland, OH USA

[6] Louis Stokes Cleveland Dept Vet Affairs Med Ctr, Res Serv, Cleveland, OH USA

[7] Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA

[8] Case Western Reserve Univ, Dept Pharmacol, Cleveland, OH 44106 USA

[9] Case Western Reserve Univ, Dept Mol Biol, Cleveland, OH 44106 USA

[10] Case Western Reserve Univ, Dept Microbiol, Cleveland, OH 44106 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 04期

基金：

美国国家卫生研究院;

关键词：

CARBAPENEMASE; ISOLATE; ST131;

D O I：

10.1128/AAC.02587-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report here the nucleotide sequence of a novel bla(KPC-2)-harboring incompatibility group N (IncN) plasmid, pECN580, from a multidrug-resistant Escherichia coli sequence type 131 (ST131) isolate recovered from Beijing, China. pECN580 harbors beta-lactam resistance genes bla(KPC-2), bla(CTX-M-3), and bla(TEM-1); aminoglycoside acetyltransferase gene aac(6')-Ib-cr; quinolone resistance gene qnrS1; rifampin resistance gene arr-3; and trimethoprim resistance gene dfrA14. The emergence of a bla(KPC-2)-harboring multidrug-resistant plasmid in an epidemic E. coli ST131 clone poses a significant potential threat in community and hospital settings.

引用

页码：2422 / 2425

页数：4

共 24 条

[1]

[Anonymous], 2012, METH DIL ANT SUSC TE

[2] The RAST server: Rapid annotations using subsystems technology [J].

Aziz, Ramy K. ;

Bartels, Daniela ;

Best, Aaron A. ;

DeJongh, Matthew ;

Disz, Terrence ;

Edwards, Robert A. ;

Formsma, Kevin ;

Gerdes, Svetlana ;

Glass, Elizabeth M. ;

Kubal, Michael ;

Meyer, Folker ;

Olsen, Gary J. ;

Olson, Robert ;

Osterman, Andrei L. ;

Overbeek, Ross A. ;

McNeil, Leslie K. ;

Paarmann, Daniel ;

Paczian, Tobias ;

Parrello, Bruce ;

Pusch, Gordon D. ;

Reich, Claudia ;

Stevens, Rick ;

Vassieva, Olga ;

Vonstein, Veronika ;

Wilke, Andreas ;

Zagnitko, Olga .

BMC GENOMICS, 2008, 9 (1)

[3] Complete nucleotide sequence of the IncN plasmid pKOX105 encoding VIM-1, QnrS1 and SHV-12 proteins in Enterobacteriaceae from Bolzano, Italy compared with IncN plasmids encoding KPC enzymes in the USA [J].

Carattoli, Alessandra ;

Aschbacher, Richard ;

March, Albert ;

Larcher, Clara ;

Livermore, David M. ;

Woodford, Neil .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2010, 65 (10) :2070-2075

[4] Resistance Plasmid Families in Enterobacteriaceae [J].

Carattoli, Alessandra .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (06) :2227-2238

[5] Control of plasmid DNA replication by iterons: no longer paradoxical [J].

Chattoraj, DK .

MOLECULAR MICROBIOLOGY, 2000, 37 (03) :467-476

[6] Complete Nucleotide Sequences of blaKPC-4- and blaKPC-5-Harboring IncN and IncX Plasmids from Klebsiella pneumoniae Strains Isolated in New Jersey [J].

Chen, Liang ;

Chavda, Kalyan D. ;

Fraimow, Henry S. ;

Mediavilla, Jose R. ;

Melano, Roberto G. ;

Jacobs, Michael R. ;

Bonomo, Robert A. ;

Kreiswirth, Barry N. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (01) :269-276

[7] Multiplex Real-Time PCR for Detection of an Epidemic KPC-Producing Klebsiella pneumoniae ST258 Clone [J].

Chen, Liang ;

Chavda, Kalyan D. ;

Mediavilla, Jose R. ;

Zhao, Yanan ;

Fraimow, Henry S. ;

Jenkins, Stephen G. ;

Levi, Michael H. ;

Hong, Tao ;

Rojtman, Albert D. ;

Ginocchio, Christine C. ;

Bonomo, Robert A. ;

Kreiswirth, Barry N. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (06) :3444-3447

[8] Multiplex Real-Time PCR Assay for Detection and Classification of Klebsiella pneumoniae Carbapenemase Gene (blaKPC) Variants [J].

Chen, Liang ;

Mediavilla, Jose R. ;

Endimiani, Andrea ;

Rosenthal, Marnie E. ;

Zhao, Yanan ;

Bonomo, Robert A. ;

Kreiswirth, Barry N. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2011, 49 (02) :579-585

[9] KPC-2-encoding plasmids from Escherichia coli and Klebsiella pneumoniae in Taiwan [J].

Chen, Ying-Tsong ;

Lin, Jung-Chung ;

Fung, Chang-Phone ;

Lu, Po-Liang ;

Chuang, Yin-Ching ;

Wu, Tsu-Lan ;

Siu, L. Kristopher .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2014, 69 (03) :628-631

[10]

Clinical and Laboratory Standards Institute, 2020, Performance Standards for Antimicrobial Susceptibility Testing

← 1 2 3 →