Physical exercise interventions have no effect on serum BDNF concentration in older adults living in long-term nursing homes

被引：8

作者：

Rezola-Pardo, Chloe ^{[1
]}

Hervas, Gotzone ^{[1
]}

Arrieta, Haritz ^{[2
,3
]}

Hernandez-de Diego, Alejandra ^{[4
]}

Ruiz-Litago, Fatima ^{[1
]}

Maria Gil, Susana ^{[1
]}

Rodriguez-Larrad, Ana ^{[1
]}

Irazusta, Jon ^{[1
]}

机构：

[1] Univ Basque Country, Fac Med & Nursery, Dept Physiol, Bo Sarriena S-N, Leioa 48940, Bizkaia, Spain

[2] Univ Basque Country UPV EHU, Fac Med & Nursery, Dept Nursing 2, Paseo Dr J Beguiristain 105, Donostia san Sebastian 20014, Gipuzkoa, Spain

[3] Onkologikoa Fdn, Paseo Doctor Beguiristain 121, Donostia san Sebastian 20014, Gipuzkoa, Spain

[4] Zorroaga Fdn, Alto Zorroaga 1, Donostia san Sebastian 20014, Gipuzkoa, Spain

来源：

EXPERIMENTAL GERONTOLOGY | 2020年 / 139卷

关键词：

BDNF; Physical exercise; Cognition; Physical performance; Long-term nursing home; Quality of life; NEUROTROPHIC FACTOR BDNF; CARDIORESPIRATORY FITNESS; MULTICOMPONENT EXERCISE; RESISTANCE EXERCISE; PERFORMANCE; TASK; ASSOCIATION; RESIDENTS; BALANCE; IMPACT;

D O I：

10.1016/j.exger.2020.111024

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Physical exercise protects against age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) may mediate some of the cognitive benefits of physical exercise, but the effect of physical exercise on serum BDNF is unclear. Indeed, differential findings have been reported depending on the characteristics of the participants and the intensity, duration, and type of exercise. The aim of this study was to determine whether three different physical exercise interventions alter serum BDNF levels in older adults living in long-term nursing homes (LTNHs) and whether changes in physical, cognitive, and dual-task performance are related to changes in serum BDNF. LTNH study participants (n = 126) were randomly assigned to multicomponent or dual-task training or a walking program and serum BDNF levels were analyzed by ELISA. We also assessed physical, cognitive, and dual-task parameters. Neither the multicomponent, dual-task, nor walking exercise programs caused changes in serum BDNF concentration in older adults living in LTNHs. Changes in BDNF during the interventions were not significantly associated with modifications in physical, cognitive or dual-task performance parameters. Our results provide new evidence clarifying the relationship between physical and cognitive exercise and BDNF.

引用

页数：7

共 74 条

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