Patient Selection and Clinical Outcomes of Y90 in Hepatocellular Carcinoma

被引：17

作者：

Wehrenberg-Klee, Eric ^{[1
]}

Gandhi, Ripal T. ^{[2
,3
]}

Ganguli, Suvranu ^{[1
]}

机构：

[1] Harvard Med Sch, Div Intervent Radiol, Massachusetts Gen Hosp, Boston, MA 02114 USA

[2] Miami Cardiac & Vasc Inst, Miami, FL USA

[3] Miami Canc Inst, Miami, FL USA

来源：

TECHNIQUES IN VASCULAR AND INTERVENTIONAL RADIOLOGY | 2019年 / 22卷 / 02期

关键词：

Y90; radioembolization; hepatocellular carcinoma; HCC; INTERNAL RADIATION-THERAPY; LIVER-CANCER; RADIOEMBOLIZATION; EFFICACY; SAFETY; CHEMOEMBOLIZATION; BRIDGE; MICROSPHERES; RADIOTHERAPY; SORAFENIB;

D O I：

10.1053/j.tvir.2019.02.006

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Y90 radioembolization is an alternative to transarterial chemoembolization for the intra-arterial treatment of hepatocellular carcinoma (HCC). However, the optimal treatment of HCC varies by tumor stage, underlying liver function and functional status, and local expertise. Therefore, the appropriate selection of patients for Y90 radioembolization is of paramount importance for optimal outcomes. Data on the role of Y90 radioembolization for HCC are most robust in the palliative treatment of inoperable, liver-confined disease. However, data are also present on the role of Y90 radioembolization as a bridge to or to downstage patients for transplant. Outcomes for radiation segmentectomy (ablative radiation doses) with curative intent or prior to resection are also discussed. (c) 2019 Elsevier Inc. All rights reserved.

引用

页码：70 / 73

页数：4

共 31 条

[1] Radiation Segmentectomy versus Selective Chemoembolization in the Treatment of Early-Stage Hepatocellular Carcinoma [J].

Biederman, Derek M. ;

Titano, Joseph J. ;

Korff, Ricki A. ;

Fischman, Aaron M. ;

Patel, Rahul S. ;

Nowakowski, Francis S. ;

Lookstein, Robert A. ;

Kim, Edward .

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 2018, 29 (01) :30-37

[2] SIRveNIB: Selective Internal Radiation Therapy Versus Sorafenib in Asia-Pacific Patients With Hepatocellular Carcinoma [J].

Chow, Pierce K. H. ;

Gandhi, Mihir ;

Tan, Say-Beng ;

Khin, Maung Win ;

Khasbazar, Ariunaa ;

Ong, Janus ;

Choo, Su Pin ;

Cheow, Peng Chung ;

Chotipanich, Chanisa ;

Lim, Kieron ;

Lesmana, Laurentius A. ;

Manuaba, Tjakra W. ;

Yoong, Boon Koon ;

Raj, Aloysius ;

Law, Chiong Soon ;

Cua, Ian H. Y. ;

Lobo, Rolley R. ;

Teh, Catherine S. C. ;

Kim, Yun Hwan ;

Jong, Yun Won ;

Han, Ho-Seong ;

Bae, Si-Hyun ;

Yoon, Hyun-Ki ;

Lee, Rheun-Chuan ;

Hung, Chien-Fu ;

Peng, Cheng-Yuan ;

Liang, Po-Chin ;

Bartlett, Adam ;

Kok, Kenneth Y. Y. ;

Thng, Choon-Hua ;

Low, Albert Su-Chong ;

Goh, Anthony S. W. ;

Tay, Kiang Hiong ;

Lo, Richard H. G. ;

Goh, Brian K. P. ;

Ng, David C. E. ;

Lekurwale, Ganesh ;

Liew, Wei Ming ;

Gebski, Val ;

Mak, Kenneth S. W. ;

Soo, Khee Chee .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (19) :1913-+

[3]

D'Avola D, 2009, HEPATO-GASTROENTEROL, V56, P1683

[4] Prognostic factors and prevention of radioembolization-induced liver disease [J].

Gil-Alzugaray, Belen ;

Chopitea, Ana ;

Inarrairaegui, Mercedes ;

Bilbao, Jose I. ;

Rodriguez-Fraile, Macarena ;

Rodriguez, Javier ;

Benito, Alberto ;

Dominguez, Ines ;

D'Avola, Delia ;

Herrero, Jose I. ;

Quiroga, Jorge ;

Prieto, Jesus ;

Sangro, Bruno .

HEPATOLOGY, 2013, 57 (03) :1078-1087

[5] Radioembolization with Use of Yttrium-90 Resin Microspheres in Patients with Hepatocellular Carcinoma and Portal Vein Thrombosis [J].

Inarrairaegui, Mercedes ;

Thurston, Kenneth G. ;

Bilbao, Jose I. ;

D'Avola, Delia ;

Rodriguez, Macarena ;

Arbizu, Javier ;

Martinez-Cuesta, Antonio ;

Sangro, Bruno .

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 2010, 21 (08) :1205-1212

[6] Survival and pattern of tumor progression with yttrium-90 microsphere radioembolization in predominantly hepatitis B Asian patients with hepatocellular carcinoma [J].

Khor, Andrew Yu-Keat ;

Toh, Ying ;

Allen, John Carson ;

Ng, David Chee-Eng ;

Kao, Yung-Hsiang ;

Zhu, Guili ;

Choo, Su-Pin ;

Lo, Richard Hoau-Gong ;

Tay, Kiang-Hiong ;

Teo, Jin-Yao ;

Goh, Brian Kim-Poh ;

Burgmans, Mark Christiaan ;

Irani, Farah Gillian ;

Goh, Anthony Soon-Whatt ;

Chow, Pierce Kah-Hoe .

HEPATOLOGY INTERNATIONAL, 2014, 8 (03) :395-404

[7] Open-label prospective study of the safety and efficacy of glass-based yttrium 90 radioembolization for infiltrative hepatocellular carcinoma with portal vein thrombosis [J].

Kokabi, Nima ;

Camacho, Juan C. ;

Xing, Minzhi ;

El-Rayes, Bassel F. ;

Spivey, James R. ;

Knechtle, Stuart J. ;

Kim, Hyun S. .

CANCER, 2015, 121 (13) :2164-2174

[8] Comparison of Yttrium-90 Radioembolization and Transcatheter Arterial Chemoembolization for the Treatment of Unresectable Hepatocellular Carcinoma [J].

Kooby, David A. ;

Egnatashvili, Vasili ;

Srinivasan, Swetha ;

Chamsuddin, Abbas ;

Delman, Keith A. ;

Kauh, John ;

Staley, Charles A., III ;

Kim, Hyun S. .

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 2010, 21 (02) :224-230

[9] Prospective randomized pilot study of Y90+/- sorafenib as bridge to transplantation in hepatocellular carcinoma [J].

Kulik, Laura ;

Vouche, Michael ;

Koppe, Sean ;

Lewandowski, Robert J. ;

Mulcahy, Mary F. ;

Ganger, Daniel ;

Habib, Ali ;

Karp, Jennifer ;

Al-Saden, Patrice ;

Lacouture, Mario ;

Cotliar, Jonathan ;

Abecassis, Michael ;

Baker, Talia ;

Salem, Riad .

JOURNAL OF HEPATOLOGY, 2014, 61 (02) :309-317

[10] Safety and efficacy of 90Y radiotherapy for hepatocellular carcinoma with and without portal vein thrombosis [J].

Kulik, Laura M. ;

Carr, Brian I. ;

Mulcahy, Mary F. ;

Lewandowski, Robert J. ;

Atassi, Bassel ;

Ryu, Robert K. ;

Sato, Kent T. ;

Benson, Al, III ;

Nemcek, Albert A., Jr. ;

Gates, Vanessa L. ;

Abecassis, Michael ;

Omary, Reed A. ;

Salem, Riad .

HEPATOLOGY, 2008, 47 (01) :71-81

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