Cell polarity and cystic kidney disease

被引：13

作者：

Fedeles, Sorin ^{[1
]}

Gallagher, Anna Rachel ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Nephrol Sect, Dept Internal Med, New Haven, CT 06520 USA

来源：

PEDIATRIC NEPHROLOGY | 2013年 / 28卷 / 08期

关键词：

Cystic kidney disease; Cell polarity; Planar polarity; Apical junction; TYROSINE KINASE INHIBITION; NEURAL-TUBE DEFECTS; POLYCYSTIC KIDNEY; PLANAR POLARITY; SUBCELLULAR-LOCALIZATION; ASYMMETRIC LOCALIZATION; EMBRYONIC-LETHALITY; TRANSGENIC MICE; GENE-PRODUCT; E-CADHERIN;

D O I：

10.1007/s00467-012-2337-z

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Epithelial cell polarity is essential for organ development; aberrations in this process have been implicated in various diseases, including polycystic kidney disease. Establishment and maintenance of cell polarity is governed by a number of molecular processes and how these processes operate remains an interesting question. Conserved protein complexes guide both apical-basolateral polarity and planar cell polarity. In this review we discuss the recent findings that provide insights into polarity mechanisms and the intriguing crosstalk between apical-basolateral polarity and planar cell polarity, and their relationship to cystic kidney disease.

引用

页码：1161 / 1172

页数：12

共 110 条

[1]

[Anonymous], 1994, Cell, V77, P881

[2] Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome [J].

Ansley, SJ ;

Badano, JL ;

Blacque, OE ;

Hill, J ;

Hoskins, BE ;

Leitch, CC ;

Kim, JC ;

Ross, AJ ;

Eichers, ER ;

Teslovich, TM ;

Mah, AK ;

Johnsen, RC ;

Cavender, JC ;

Lewis, RA ;

Leroux, MR ;

Beales, PL ;

Katsanis, N .

NATURE, 2003, 425 (6958) :628-633

[3] A polycystic kidney-disease gene homologue required for male mating behaviour in C-elegans [J].

Barr, MM ;

Sternberg, PW .

NATURE, 1999, 401 (6751) :386-389

[4] Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division [J].

Bellaïche, Y ;

Gho, M ;

Kaltschmidt, JA ;

Brand, AH ;

Schweisguth, F .

NATURE CELL BIOLOGY, 2001, 3 (01) :50-57

[5] Loss of nephrocystin-3 function can cause embryonic lethality, meckel-gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia [J].

Bergmann, Carsten ;

Fliegauf, Manfred ;

Bruechle, Nadina Ortiz ;

Frank, Valeska ;

Olbrich, Heike ;

Kirschner, Jan ;

Schermer, Bernhard ;

Schmedding, Ingolf ;

Kispert, Andreas ;

Kraenzlin, Bettina ;

Nuernberg, Gudrun ;

Becker, Christian ;

Grimm, Tiemo ;

Girschick, Gundula ;

Lynch, Sally A. ;

Kelehan, Peter ;

Senderek, Jan ;

Neuhaus, Thomas J. ;

Stallmach, Thomas ;

Zentgraf, Hanswalter ;

Nuernberg, Peter ;

Gretz, Norbert ;

Lo, Cecilia ;

Lienkamp, Soeren ;

Schaefer, Tobias ;

Walz, Gerd ;

Benzing, Thomas ;

Zerres, Klaus ;

Omran, Heymut .

AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 82 (04) :959-970

[6] The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl [J].

Betschinger, J ;

Mechtler, K ;

Knoblich, JA .

NATURE, 2003, 422 (6929) :326-330

[7] Biochemical characterization of bona fide polycystin-1 in vitro and in vivo [J].

Boletta, A ;

Qian, F ;

Onuchic, LF ;

Bragonzi, A ;

Cortese, M ;

Deen, PM ;

Courtoy, PJ ;

Soria, MR ;

Devuyst, O ;

Monaco, L ;

Germino, GG .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2001, 38 (06) :1421-1429

[8] Defects in cell polarity underlie TSC and ADPKD-associated cystogenesis [J].

Bonnet, Cleo S. ;

Aldred, Mark ;

von Ruhland, Christopher ;

Harris, Rebecca ;

Sandford, Richard ;

Cheadle, Jeremy P. .

HUMAN MOLECULAR GENETICS, 2009, 18 (12) :2166-2176

[9] Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia [J].

Borovina, Antonia ;

Superina, Simone ;

Voskas, Daniel ;

Ciruna, Brian .

NATURE CELL BIOLOGY, 2010, 12 (04) :407-U242

[10] Developmental compartments and planar polarity in Drosophila [J].

Casal, J ;

Struhl, G ;

Lawrence, PA .

CURRENT BIOLOGY, 2002, 12 (14) :1189-1198

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