Discovery of novel isatin-dehydroepiandrosterone conjugates as potential anticancer agents

被引：39
作者：
Ke, Shaoyong [1 ]
Shi, Liqiao [1 ]
Yang, Ziwen [1 ]
机构：
[1] Hubei Acad Agr Sci, Natl Biopesticide Engn Res Ctr, Wuhan 430064, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 20期
关键词：
Isatin; Dehydroepiandrosterone; Hybrids; Synthesis; Antitumor activity; IN-VITRO; DERIVATIVES; DESIGN;
D O I：
10.1016/j.bmcl.2015.08.041
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of isatin-dehydroepiandrosterone hybrids were synthesised via a convenient condensation procedure, and which were evaluated for their potential anticancer activities. The preliminary assays indicated that some of the newly obtained compounds exhibited good antitumor activities against human hepatocellular liver carcinoma (HepG2), heptoma (Huh-7), melanoma (A875) and 5-fluorouracil-resistant human hepatocellular carcinoma (BEL-7402/5-FU) cell lines compared with 5-fluorouracil (5-FU), which might be considered as promising lead scaffold for further design and synthesis of highly potential anticancer agents. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4628 / 4631
页数：4
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