The complexity of adverse side-effects to biological agents

被引：42

作者：

Aubin, Francois ^{[1
,2
]}

Carbonnel, Franck ^{[3
]}

Wendling, Daniel ^{[4
,5
]}

机构：

[1] Univ Franche Comte, EA3181, F-25030 Besancon, France

[2] CHU Besancon, Serv Dermatol, F-25030 Besancon, France

[3] Univ Paris 11, CHU Bicetre, AP HP, Serv Hepatogastroenterol, Paris, France

[4] CHU Besancon, Serv Rhumatol, F-25030 Besancon, France

[5] Univ Franche Comte, F-25030 Besancon, France

来源：

JOURNAL OF CROHNS & COLITIS | 2013年 / 7卷 / 04期

关键词：

Biologics; Side effects; Adverse events; TUMOR-NECROSIS-FACTOR; RHEUMATOID-ARTHRITIS; CROHNS-DISEASE; HYPERSENSITIVITY REACTIONS; INTERFERON-ALPHA; DRUG-REACTIONS; INFLIXIMAB; THERAPY; ANTIBODIES; BLOCKADE;

D O I：

10.1016/j.crohns.2012.06.024

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Whereas adverse effects induced by xenobiotics are mainly linked to the pharmacological effect, the adverse side-effects induced by biological agents (BA) are often target-related and linked to the biological consequences of their action. Based on these differences, an original classification of the adverse effects has been proposed. Five types of adverse effects induced by BA are described (alpha, beta, gamma, delta and epsilon). This classification provides a very useful scheme for a better understanding of these adverse effects. This approach should help to better characterize the pathogenic mechanisms involved and to optimize their management. Healthcare professionals should be aware of the specific risks related to this relatively new class of drugs. Close monitoring of these BA is therefore recommended. (c) 2012 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

引用

页码：257 / 262

页数：6

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