Overhydration Negatively Affects Quality of Life in Peritoneal Dialysis Patients: Evidence from a Prospective Observational Study

被引：24

作者：

Yoon, Hye Eun ^{[1
]}

Kwon, Young Joo ^{[2
]}

Song, Ho Cheol ^{[3
]}

Kim, Jin Kuk ^{[4
]}

Song, Young Rim ^{[5
]}

Shin, Seok Joon ^{[1
]}

Kim, Hyung Wook ^{[6
]}

Lee, Chang Hwa ^{[7
]}

Lee, Tae Won ^{[8
]}

Kim, Young Ok ^{[9
]}

Kim, Byung Soo ^{[10
]}

Moon, Kyoung Hyoub ^{[11
]}

Chang, Yoon Kyung ^{[12
]}

Kim, Seong Suk ^{[13
]}

Bang, Kitae ^{[14
]}

Cho, Jong Tae ^{[15
]}

Yun, Sung Ro ^{[16
]}

Na, Ki Ryang ^{[17
]}

Kim, Yang Wook ^{[18
]}

Han, Byoung Geun ^{[19
]}

Chung, Jong Hoon ^{[20
]}

Lee, Kwang Young ^{[21
]}

Jeong, Jong Hyeok ^{[22
]}

Hwang, Eun Ah ^{[23
]}

Kim, Yong-Soo ^{[24
]}

机构：

[1] Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Internal Med, Seoul, South Korea

[2] Korea Univ, Guro Hosp, Dept Internal Med, Seoul, South Korea

[3] Catholic Univ Korea, Bucheon St Marys Hosp, Dept Internal Med, Seoul, South Korea

[4] Soonchunhyang Univ, Bucheon Hosp, Dept Internal Med, Asan, Chungcheong, South Korea

[5] Hallym Univ, Sacred Heart Hosp, Dept Internal Med, Chunchon, Gangwon, South Korea

[6] Catholic Univ Korea, St Vincents Hosp, Dept Internal Med, Seoul, South Korea

[7] Hanyang Univ, Med Ctr, Dept Internal Med, Seoul, South Korea

[8] Kyung Hee Univ, Med Ctr, Dept Internal Med, Seoul, South Korea

[9] Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Internal Med, Seoul, South Korea

[10] Catholic Univ Korea, St Pauls Hosp, Dept Internal Med, Seoul, South Korea

[11] Vet Hlth Serv Med Ctr, Dept Internal Med, Seoul, South Korea

[12] Catholic Univ Korea, Daejeon St Marys Hosp, Dept Internal Med, Seoul, South Korea

[13] Daejeon Sun Hosp, Dept Internal Med, Jung, Daejeon, South Korea

[14] Eulji Univ Hosp, Dept Internal Med, Seongnam, Gyeonggi, South Korea

[15] Dankook Univ Hosp, Dept Internal Med, Yongin, Gyeonggi, South Korea

[16] Konyang Univ Hosp, Dept Internal Med, Nonsan, South Korea

[17] Chungnam Natl Univ Hosp, Dept Internal Med, Daejeon, South Korea

[18] Inje Univ, Haeundae Paik Hosp, Dept Internal Med, Gimhae, South Korea

[19] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Seoul 120749, South Korea

[20] Chosun Univ Hosp, Dept Internal Med, Gwangju, South Korea

[21] Presbyterian Med Ctr, Dept Internal Med, Philadelphia, PA 19104 USA

[22] St Carollo Hosp, Dept Internal Med, Sunchon, South Korea

[23] Keimyung Univ, Dongsan Med Ctr, Dept Internal Med, Daegu, South Korea

[24] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med, 222 Banpo daero, Seoul 06591, South Korea

来源：

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2016年 / 13卷 / 09期

关键词：

bioimpedance; fluid overload; overhydration; peritoneal dialysis; quality of life; FLUID STATUS; BIOIMPEDANCE SPECTROSCOPY; VOLUME OVERLOAD; CAPD PATIENTS; DEPRESSION; ASSOCIATION; SURVIVAL; ABNORMALITIES; BIOMARKERS; MORTALITY;

D O I：

10.7150/ijms.16372

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Backgound: This study evaluated whether the hydration status affected health-related quality of life (HRQOL) during 12 months in peritoneal dialysis (PD) patients. Methods: The hydration status and the HRQOL were examined at baseline and after 12 months using a bioimpedance spectroscopy and Kidney Disease Quality of Life-Short Form, respectively in PD patients. Four hundred eighty-one patients were included and divided according to the baseline overhydration (OH) value; normohydration group (NH group, -2L <= OH <=+2L, n=266) and overhydration group (OH group, OH >+2L, n=215). Baseline HRQOL scores were compared between the two groups. The subjects were re-stratified into quartiles according to the OH difference (OH value at baseline - OH value at 12 months; <-1, -1 - -0.1, -0.1 - +1, and >=+1L). The relations of OH difference with HRQOL scores at 12 months and the association of OH difference with the HRQOL score difference (HRQOL score at baseline - HRQOL score at 12 months) were assessed. Results: The OH group showed significantly lower baseline physical and mental health scores (PCS and MCS), and kidney disease component scores (KDCS) compared with the NH group (all, P<0.01). At 12 months, the adjusted PCS, MCS, and KDCS significantly increased as the OH difference quartiles increased (P<0.001, P=0.002, P<0.001, respectively). In multivariate analysis, the OH difference was independently associated with higher PCS (beta = 2.04, P<.001), MCS (beta=1.02, P=0.002), and KDCS (beta=1.06, P<0.001) at 12 months. The OH difference was independently associated with the PCS difference (beta = -1.81, P<0.001), MCS difference (beta=-0.92, P=0.01), and KDCS difference (beta=-0.90, P=0.001). Conclusion: The hydration status was associated with HRQOL and increased hydration status negatively affected HRQOL after 12 months in PD patients.

引用

页码：686 / 695

页数：10

共 33 条

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