The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer

被引：30
作者：
Barber, MD
McMillan, DC [1 ]
Wallace, AM
Ross, JA
Preston, T
Fearon, KCH
机构：
[1] Univ Glasgow, Royal Infirm, Dept Surg, Glasgow G31 2ER, Lanark, Scotland
[2] Univ Edinburgh, Royal Infirm Edinburgh, Dept Surg, Edinburgh EH3 9YW, Midlothian, Scotland
[3] Royal Infirm, Dept Clin Biochem, Glasgow G31 2ER, Lanark, Scotland
[4] Scottish Univ Environm Res Ctr, Isotope Biochem Lab, Glasgow G75 0QF, Lanark, Scotland
来源：
BRITISH JOURNAL OF CANCER | 2004年 / 90卷 / 06期
关键词：
leptin; interleukin-6; insulin; cortisol; fat oxidation; feeding; weight loss; pancreatic cancer;
D O I：
10.1038/sj.bjc.6601712
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
At baseline, weight-losing pancreatic cancer patients (n = 7) had lower leptin (P < 0.05) but higher cortisol, interleukin-6, resting energy expenditure and fat oxidation than healthy subjects (n = 6, P < 0.05). Over a 4 h feeding period, the areas under the curve for glucose, cortisol and interleukin-6 were greater (P < 0.05), but less for leptin in the cancer group (P < 0.05). Therefore, it would appear that low leptin concentrations, increased fat oxidation and insulin resistance are associated with increased concentrations of cortisol and interleukin-6 in weight-losing patients with pancreatic cancer.
引用
收藏
页码：1129 / 1132
页数：4
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