Mechanical cell competition

被引:49
作者
Bras-Pereira, Catarina [1 ]
Moreno, Eduardo [1 ]
机构
[1] Champalimaud Ctr Unknown, Cell Fitness Lab, P-1400038 Lisbon, Portugal
基金
瑞士国家科学基金会; 欧洲研究理事会;
关键词
BETA-CATENIN ACTIVATION; FITNESS FINGERPRINTS; ION-CHANNEL; STEM-CELLS; GROWTH; DROSOPHILA; MECHANOTRANSDUCTION; YAP/TAZ; CANCER; PIEZO1;
D O I
10.1016/j.ceb.2017.10.003
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Maintenance of tissue organization is crucial to ensure normal organ function and organism viability. Tissues are loaded with the ability to sense the available space, measuring cell density and adapting their behaviour accordingly. To keep homeostasis, compression pressure generated by local cell density increment triggers cell elimination. During mechanical cell competition, winner cells compress the neighbouring cells, promoting tissue crowding, which leads to cell elimination. Thus, the hypersensitivity to crowding may confer a loser status, whereas resistance to mechanical-induced elimination may favour a winner status. Here we analyse the emerging field of mechanical cell competition, describing the mechanotransducers implicated in cell elimination. Furthermore, we highlight the dual role of mechanical cell competition (MCC) as tumour suppression or expansion mechanisms.
引用
收藏
页码:15 / 21
页数:7
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