Ugi Four-Component Reaction with Tandem Deprotection, Cyclization and Pictet-Spengler Reaction: A Concise Route to N-Fused Polycyclic Indolediketopiperazine Alkaloid Analogues

被引：14

作者：

Tyagi, Vikas ^{[1
]}

Khan, Shahnawaz ^{[1
]}

Chauhan, Prem M. S. ^{[1
]}

机构：

[1] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India

来源：

SYNLETT | 2013年 / 24卷 / 10期

关键词：

alkaloids; Ugi reaction; tandem reactions; deprotection; cyclization; Pictet-Spengler reaction; ASPERGILLUS SP; SUBSTANCE-P; MULTICOMPONENT REACTION; HETEROCYCLIC SCAFFOLDS; 3-COMPONENT REACTION; DIVERSE SYNTHESIS; TRYPROSTATIN B; BREVIANAMIDE E; ONE-POT; DERIVATIVES;

D O I：

10.1055/s-0033-1338707

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aza-fused polycyclic indolediketopiperazine alkaloids are of potential interest due to their broad range of biological activities. Traditionally, a number of methods have been used to generate N-fused polycyclic indolediketopiperazine skeletons, but the need to develop novel, concise methods with which to modify the substitution pattern continues. Herein, we describe the two-step formation of N-fused polycyclic indolediketopiperazine alkaloid analogues by the application of the Ugi four-component reaction with tandem deprotection, cyclization and Pictet-Spengler reaction.

引用

页码：1291 / 1297

页数：7

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