Pressurised intraperitoneal aerosolised chemotherapy (PIPAC) for gastric cancer with peritoneal metastases: A systematic review by the PIPAC UK collaborative

被引：15
作者：
Case, A. [1 ,2 ]
Prosser, S. [1 ]
Peters, C. J. [3 ]
Adams, R. [4 ,5 ]
Gwynne, S. [1 ,2 ]
机构：
[1] Singleton Hosp, South West Wales Canc Ctr, Sketty Lane, Swansea SA2 8QA, Wales
[2] Swansea Univ, Med Sch, Grove Bldg, Singleton Pk, Swansea SA2 8PP, Wales
[3] Imperial Coll London, St Marys Hosp, Dept Surg & Canc, Praed St, London W2 1NY, England
[4] Cardiff Univ, Ctr Trials Res, Velindre Rd, Whitchurch CF14 2TL, England
[5] Velindre Canc Ctr, Velindre Rd, Whitchurch CF14 2TL, England
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2022年 / 180卷
关键词：
Pressurised intraperitoneal aerosolized  chemotherapy; PIPAC; Gastric cancer; Peritoneal metastases; LOW-DOSE CISPLATIN; OPEN-LABEL; DOXORUBICIN;
D O I：
10.1016/j.critrevonc.2022.103846
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Introduction: Gastric cancer with peritoneal metastases (GCPM) carries a poor prognosis. Pressurised Intraperi-toneal Aerosolised Chemotherapy (PIPAC) offers pharmacokinetic advantages over intravenous therapy, resulting in higher chemotherapy concentrations in peritoneal deposits, and potentially reduced systemic ab-sorption/toxicity. This review evaluates efficacy, tolerability and impact on quality of life (QOL) of PIPAC for GCPM.Methods: Following registration with PROSPERO (CRD42021281500), MEDLINE, EMBASE and The Cochrane Library were searched for PIPAC in patients with peritoneal metastases, in accordance with PRISMA standardsResults: Across 18 included reports representing 751 patients with GCPM (4 prospective, 11 retrospective, 3 abstracts, no phase III studies), median overall survival (mOS) was 8 - 19.1 months, 1-year OS 49.8-77.9%, complete response (PRGS1) 0-35% and partial response (PRGS2/3) 0-83.3%. Grade 3 and 4 toxicity was 0.7-25% and 0-4.1% respectively. Three studies assessing QOL reported no significant difference.Conclusion: PIPAC may offer promising survival benefits, toxicity, and QOL for GCPM.
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页数：16
相关论文
共 63 条
[41]   Pressurized intraperitoneal aerosol chemotherapy (PIPAC) for peritoneal malignancy: initial experience of the first program in the Baltic countries [J].
Rackauskas, Rokas ;
Bausys, Augustinas ;
Luksta, Martynas ;
Jurgaitis, Jonas ;
Paskonis, Marius ;
Strupas, Kestutis .
WORLD JOURNAL OF SURGICAL ONCOLOGY, 2021, 19 (01)
[42]  
Raoof M., 2022, ANN SURG ONCOL, V29, P175, DOI [10.1245/s10434-021-10505-0, DOI 10.1245/s10434-021-10505-0]
[43]   The Burden of Peritoneal Metastases from Gastric Cancer: A Systematic Review on the Incidence, Risk Factors and Survival [J].
Rijken, Anouk ;
Lurvink, Robin J. ;
Luyer, Misha D. P. ;
Nieuwenhuijzen, Grard A. P. ;
van Erning, Felice N. ;
van Sandick, Johanna W. ;
de Hingh, Ignace H. J. T. .
JOURNAL OF CLINICAL MEDICINE, 2021, 10 (21)
[44]   Radiologist Checklist for Selecting Patients to Undergo PIPAC (Pressurized IntraPeritoneal Aerosol Chemotherapy) [J].
Rodolfino, Elena ;
Di Marco, Margo' ;
Ilot, Alessia ;
Iezzi, Roberto ;
Gui, Benedetta ;
Avesani, Giacomo ;
Panico, Camilla ;
Strippoli, Antonia ;
Di Giorgio, Andrea ;
Pacelli, Fabio ;
Manfredi, Riccardo .
LIFE-BASEL, 2021, 11 (09)
[45]   Consensus statement for treatment protocols in pressurized intraperitoneal aerosol chemotherapy (PIPAC) [J].
Sgarbura, Olivia ;
Eveno, Clarisse ;
Alyami, Mohammad ;
Bakrin, Naoual ;
Guiral, Delia Cortes ;
Ceelen, Wim ;
Delgadillo, Xavier ;
Dellinger, Thanh ;
Di Giorgio, Andrea ;
Kefleyesus, Amaniel ;
Khomiakov, Vladimir ;
Mortensen, Michael Bau ;
Murphy, Jamie ;
Pocard, Marc ;
Reymond, Marc ;
Robella, Manuela ;
Rovers, Koen P. ;
So, Jimmy ;
Somashekhar, S. P. ;
Tempfer, Clemens ;
Van der Speeten, Kurt ;
Villeneuve, Laurent ;
Yong, Wei Peng ;
Hubner, Martin .
PLEURA AND PERITONEUM, 2022, 7 (01) :1-7
[46]   Current practice of pressurized intraperitoneal aerosol chemotherapy (PIPAC): Still standardized or on the verge of diversification? [J].
Sgarbura, Olivia ;
Villeneuve, Laurent ;
Alyami, Mohammad ;
Bakrin, Naoual ;
Torrent, Juan Jose ;
Eveno, Clarisse ;
Huebner, Martin .
EJSO, 2021, 47 (01) :149-156
[47]   Oxaliplatin use in pressurized intraperitoneal aerosol chemotherapy (PIPAC) is safe and effective: A multicenter study [J].
Sgarbura, Olivia ;
Hubner, Martin ;
Alyami, Mohammad ;
Eveno, Clarisse ;
Gagniere, Johan ;
Pache, Basile ;
Pocard, Marc ;
Bakrin, Naoual ;
Quenet, Francois .
EJSO, 2019, 45 (12) :2386-2391
[48]   Severe hypersensitivity reactions to platinum compounds post-pressurized intraperitoneal aerosol chemotherapy (PIPAC): first literature report [J].
Siebert, Matthieu ;
Alyami, Mohammad ;
Mercier, Frederic ;
Gallice, Colin ;
Villeneuve, Laurent ;
Berard, Frederic ;
Glehen, Olivier ;
Bakrin, Naoual ;
Kepenekian, Vahan .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2019, 83 (03) :425-430
[49]   Clinical Outcome for Patients Managed with Low-Dose Cisplatin and Doxorubicin Delivered as Pressurized Intraperitoneal Aerosol Chemotherapy for Unresectable Peritoneal Metastases of Gastric Cancer [J].
Sindayigaya, Remy ;
Dogan, Can ;
Demtroeder, Cedric Remy ;
Fischer, Britta ;
Karam, Elias ;
Buggisch, Jonathan Robin ;
Tempfer, Clemens B. ;
Lecomte, Thierry ;
Ouaissi, Mehdi ;
Giger-Pabst, Urs .
ANNALS OF SURGICAL ONCOLOGY, 2022, 29 (01) :112-123
[50]   Reproducibility of the peritoneal regression grading score for assessment of response to therapy in peritoneal metastasis [J].
Solass, Wiebke ;
Sempoux, Christine ;
Carr, Norman J. ;
Bibeau, Frederic ;
Neureiter, Daniel ;
Jaeger, Tarkan ;
Di Caterino, Tina ;
Brunel, Christophe ;
Klieser, Eckhard ;
Fristrup, Claus W. ;
Mortensen, Michael B. ;
Detlefsen, Sonke .
HISTOPATHOLOGY, 2019, 74 (07) :1014-1024
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