Small RNA-directed heterochromatin formation in the context of development: What flies might learn from fission yeast

被引：25
作者：
Huisinga, Kathryn L. [1 ]
Elgin, Sarah C. R. [1 ]
机构：
[1] Washington Univ, Dept Biol, St Louis, MO 63130 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2009年 / 1789卷 / 01期
关键词：
Heterochromatin; Drosophila melanogaster; Small RNA; S; pombe; Transposable element; Cell cycle; DROSOPHILA-MELANOGASTER DEVELOPMENT; EMBRYONIC AXIS SPECIFICATION; POSITION-EFFECT VARIEGATION; SELFISH GENETIC ELEMENTS; POLE CELL-FORMATION; TELOMERE ELONGATION; ENDOGENOUS SIRNAS; DNA METHYLATION; SOMATIC-CELLS; GERM-LINE;
D O I：
10.1016/j.bbagrm.2008.08.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A link between the RNAi system and heterochromatin formation has been established in several model organisms including Schizosaccharomyces pombe and Arabidopsis thaliana. However, the data to support a role for small RNAs and the associated machinery in transcriptional gene silencing in animal systems is more tenuous. Using the S. pombe system as a model, we analyze the role of small RNA pathway components and associated small RNAs in regulating transposable elements and potentially directing heterochromatin formation at these elements in Drosophila melanogaster. (C) 2008 Elsevier B.V. All rights reserved.
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收藏
页码：3 / 16
页数：14
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