One-Pot Synthesis of Papaverine Hydrochloride and Identification of Impurities

被引：3
|
作者：
Yu, Wen-Shuai [1 ,2 ]
Wu, Ze-Nong [2 ,3 ]
Qiu, Zeng-Feng [4 ]
Zhao, Chun-Jie [1 ]
Zhang, Fu-Li [2 ]
Yang, Zhe-Zhou [2 ]
机构：
[1] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China
[2] China State Inst Pharmaceut Ind, Shanghai Inst Pharmaceut Ind, Shanghai 201203, Peoples R China
[3] Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
[4] Shandong Agr Univ, Coll Chem & Mat Sci, Tai An 271018, Shandong, Peoples R China
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 56卷 / 07期
关键词：
papaverine hydrochloride; one-pot synthesis; impurities; efficiency; DESIGN;
D O I：
10.1134/S1070428020070258
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot synthesis of papaverine hydrochloride with 99.6% purity was performed using xylene as solvent for the entire process. The critical parameters of each step, as well as the impurities generated, were identified. The overall yield was improved to 63%. The proposed synthetic procedure is suitable for industrial production.
引用
收藏
页码：1295 / 1299
页数：5
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