Combination of immunotherapy with chemotherapy and radiotherapy in lung cancer: is this the beginning of the end for cancer?

被引：103

作者：

Lazzari, Chiara ^{[1
]}

Karachaliou, Niki ^{[2
,3
]}

Bulotta, Alessandra ^{[1
]}

Vigano, Mariagrazia ^{[1
]}

Mirabile, Aurora ^{[1
]}

Brioschi, Elena ^{[1
]}

Santarpia, Mariacarmela ^{[4
]}

Gianni, Luca ^{[1
]}

Rosell, Rafael ^{[5
,6
,7
]}

Gregorc, Vanesa ^{[1
]}

机构：

[1] IRCCS San Raffaele, Dept Oncol, Div Expt Med, Via Olgettina 60, I-20132 Milan, Lombardia, Italy

[2] Univ Hosp Sagrat Cor, Inst Oncol Dr Rosell IOR, Barcelona, Spain

[3] Quiron Dexeus Univ Inst, Coyote Res Grp, Lab Mol Biol, Pangaea Oncol, Barcelona, Spain

[4] Univ Messina, Dept Human Pathol G Barresi, Med Oncol Unit, Messina, Italy

[5] Quiron Dexeus Univ Inst, Inst Oncol Dr Rosell IOR, Barcelona, Spain

[6] Inst Invest Ciencies Germans Trias & Pujol, Badalona, Spain

[7] Hosp Badalona Germans Trias & Pujol, Inst Catala Oncol, Badalona, Spain

来源：

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY | 2018年 / 10卷

关键词：

chemotherapy; immune checkpoint inhibitors; immune evasion; immune resistance; non-small cell lung cancer; PD-1; inhibitors; PD-L1; radiotherapy; PHASE-III TRIAL; CISPLATIN PLUS GEMCITABINE; RADIATION-THERAPY; PD-1; BLOCKADE; 1ST-LINE TREATMENT; TUMOR; NIVOLUMAB; DOCETAXEL; CARBOPLATIN; PEMBROLIZUMAB;

D O I：

10.1177/1758835918762094

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune checkpoint inhibitors have significantly improved overall survival with an acceptable safety profile in a substantial proportion of non-small cell lung cancer (NSCLC) patients. However, not all patients are sensitive to immune checkpoint blockade and, in some cases, programmed death 1 (PD-1) or programmed death ligand 1 (PD-L1) inhibitors accelerate tumor progression. Several combination strategies are under evaluation, including the concomitant or sequential evaluation of chemotherapy or radiotherapy with immunotherapy. The current review provides an overview on the molecular rationale for the investigation of combinatorial approaches with chemotherapy or radiotherapy. Moreover, the results of completed clinical studies will be reported.

引用

页码：1 / 12

页数：12

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