Antibodies to phosphatidylserine/prothrombin complex in suspected antiphospholipid syndrome in the absence of antibodies to cardiolipin or Beta-2-glycoprotein I

被引：15

作者：

Sanfelippo, M. J. ^{[1
]}

Joshi, A. ^{[2
]}

Schwartz, S. L. ^{[1
]}

Meister, J. A. ^{[1
]}

Goldberg, J. W. ^{[3
]}

机构：

[1] Marshfield Clin Fdn Med Res & Educ, Dept Lab Med, Marshfield, WI USA

[2] Marshfield Clin Fdn Med Res & Educ, Dept Internal Med, Marshfield, WI USA

[3] Marshfield Clin Fdn Med Res & Educ, Dept Rheumatol, Marshfield, WI USA

来源：

LUPUS | 2013年 / 22卷 / 13期

关键词：

Antibodies; phosphatidylserine; prothrombin; antiphospholipid syndrome;

D O I：

10.1177/0961203313497120

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antibodies to phosphatidylserine/prothrombin (aPS/PT) complex were measured in 728 serum specimens from patients suspected of having antiphospholipid syndrome (APS), but without diagnostic elevations in the levels of antibodies to cardiolipin or Beta-2 Glycoprotein 1 (2-GP1). Of the 728 specimens, 41 had elevated levels of aPS/PT. Thrombotic events occurred in 11 of the 22 patients with accessible medical histories. Six of the patients with accessible medical records also had laboratory evidence of the lupus anticoagulant. The identification of aPS/PT in patients without evidence of antibodies to cardiolipin, 2-GP1, or the lupus anticoagulant can contribute to the identification of APS in patients that may go undetected with current testing methods.

引用

页码：1349 / 1352

页数：4

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