Relationship between α-fetoprotein and fetal erythropoiesis

被引:0
作者
Bartha, JL
Comino-Delgado, R
Arce, R
Alba, P
Broullon, JR
Barahona, M
机构
[1] Univ Cadiz, Serv Obstet & Ginecol, Univ Hosp, Dept Obstet & Gynecol, Cadiz 11510, Spain
[2] Univ Cadiz, Univ Hosp, Dept Clin Chem, Cadiz 11510, Spain
[3] Univ Cadiz, Univ Hosp, Dept Hematol, Cadiz 11510, Spain
关键词
alpha-fetoproteins; erythropoiesis; fetus;
D O I
暂无
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: To evaluate the relationship of fetal erythropoiesis to both maternal and fetal serum alpha-fetoprotein (AFP) levels. STUDY DESIGN: We evaluated the relationships between maternal serum AFP levels and fetal hemoglobin, hematocrit, red blood cell count, mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration in 63 fetuses, 19 of them by prenatal cordocentesis and 44 at elective cesarean section before labor. We also evaluated the relationships between fetal AFP and fetal hemoglobin, hematocrit, red blood cell count, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, erythroblasts, erythropoietin, serum iron, transferrin, ferritin, bilirubin, total proteins and albumin in 51 umbilical cords immediately after singleton childbirth, in healthy, pregnant women at term. Statistical analysis was performed by linear regression. RESULTS: After adjustment according to gestational age, significant correlations were found between maternal AFP and fetal hemoglobin (r = -.30, P = .017) and hematocrit (r = -.25, P = .044). We also found a significant negative correlation between fetal serum alpha-fetoprotein and fetal red blood cells (r = -.55, P = .000026), hemoglobin (r = -.40, P = .0035), hematocrit (r = -.46, P = .00052), erythropoietin (r = -.40, P = .005) and transferrin (r = -.33, P = .016). Erythropoietin also positively correlated with fetal red blood cells (r = .47, P = .001), hemoglobin (r = .45, P = .001), hematocrit (r = .47, P = .001) and erythroblasts (r = .42, P = .003). CONCLUSION: Since a significant negative correlation was demonstrated between fetal red blood cell count, hemoglobin, hematocrit, erythropoietin and AFP, it is reasonable to speculate that AFP could play a role in fetal erythropoiesis.
引用
收藏
页码:689 / 697
页数:9
相关论文
共 25 条
[1]   Maternal serum alpha-fetoprotein in placental abruption associated with preterm labor [J].
Bartha, JL ;
CominoDelgado, R ;
Arce, F .
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 1997, 56 (03) :231-236
[2]   WHY MIGHT MATERNAL SERUM AFP BE HIGH IN PREGNANCIES IN WHICH THE FETUS IS NORMALLY FORMED [J].
BOYD, PA .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1992, 99 (02) :93-95
[3]  
CARRINGTON D, 1987, LANCET, V1, P433
[4]  
ESTEBAN C, 1993, LEUKEMIA, V7, P1807
[5]  
EXTERMANN P, 1993, OBSTET GYNECOL, V81, P958
[6]  
GARDNER JD, 1990, BLOOD, V75, P2150
[7]   ENDOCYTOSIS OF 3 SERUM-PROTEINS OF A MULTIGENE FAMILY AND OF ARACHIDONIC-ACID IN HUMAN LECTIN-STIMULATED T-LYMPHOCYTES [J].
GEUSKENS, M ;
TORRES, JM ;
ESTEBAN, C ;
URIEL, J .
MICROSCOPY RESEARCH AND TECHNIQUE, 1994, 28 (04) :297-307
[8]  
HENRIQUES CU, 1993, OBSTET GYNECOL, V82, P960
[9]  
HWANG SJ, 1994, CHIN MED J, V53, P262
[10]  
Katz V L, 1990, Obstet Gynecol Surv, V45, P719, DOI 10.1097/00006254-199011000-00001