Molecular basis of localized responses during chemotaxis in amoebae and leukocytes

被引：33

作者：

van Es, S ^{[1
]}

Devreotes, PN ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 1999年 / 55卷 / 10期

关键词：

chemotaxis; Dictyostelium; leukocytes; chemoattractant receptors; G-proteins; signal transduction;

D O I：

10.1007/s000180050374

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Free-living amoebae as well as mammalian leukocytes sense chemoattractants with seven helix receptors linked to G-proteins. The cells respond by extending pseudopods and moving in the direction of the highest concentration. Recent studies using GFP-tagged proteins in Dietyostelium have shown that the directional response becomes sharply localized downstream of the receptors and G-proteins but upstream of the actin cytoskeleton. These studies together with the isolation novel genes by insertional mutagenesis in Dictyostelium are leading to a new understanding of chemotaxis in eucaryotic cells.

引用

页码：1341 / 1351

页数：11

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