Exercise immunology: Future directions

被引：90

作者：

Nieman, David C. ^{[1
]}

Pence, Brandt D. ^{[2
]}

机构：

[1] Appalachian State Univ, Human Performance Lab, North Carolina Res Campus, Kannapolis, NC 28081 USA

[2] Univ Memphis, Sch Hlth Studies, Memphis, TN 38152 USA

来源：

JOURNAL OF SPORT AND HEALTH SCIENCE | 2020年 / 9卷 / 05期

关键词：

Exercise; Immunology; Lipidomics; Metabolomics; Proteomics; GUT MICROBIOTA COMPOSITION; SOLUBLE EPOXIDE HYDROLASE; PLASMA-PROTEIN CHANGES; FATTY-ACID OXIDATION; MEMORY T-CELLS; ALTERNATIVE ACTIVATION; INTESTINAL MICROBIOTA; LINOLEIC-ACID; INSULIN SENSITIVITY; RESISTANCE EXERCISE;

D O I：

10.1016/j.jshs.2019.12.003

中图分类号：

F [经济];

学科分类号：

02 ;

摘要：

Several decades of research in the area of exercise immunology have shown that the immune system is highly responsive to acute and chronic exercise training. Moderate exercise bouts enhance immunosurveillance and when repeated over time mediate multiple health benefits. Most of the studies prior to 2010 relied on a few targeted outcomes related to immune function. During the past decade, technologic advances have created opportunities for a multi-omics and systems biology approach to exercise immunology. This article provides an overview of metabolomics, lipidomics, and proteomics as they pertain to exercise immunology, with a focus on immunome-tabolism. This review also summarizes how the composition and diversity of the gut microbiota can be influenced by exercise, with applications to human health and immunity. Exercise-induced improvements in immune function may play a critical role in countering immunosenescence and the development of chronic diseases, and emerging omics technologies will more clearly define the underlying mechanisms. This review summarizes what is currently known regarding a multi-omics approach to exercise immunology and provides future directions for investigators.

引用

页码：432 / 445

页数：14

共 190 条

[31] Diet rapidly and reproducibly alters the human gut microbiome [J].

David, Lawrence A. ;

Maurice, Corinne F. ;

Carmody, Rachel N. ;

Gootenberg, David B. ;

Button, Julie E. ;

Wolfe, Benjamin E. ;

Ling, Alisha V. ;

Devlin, A. Sloan ;

Varma, Yug ;

Fischbach, Michael A. ;

Biddinger, Sudha B. ;

Dutton, Rachel J. ;

Turnbaugh, Peter J. .

NATURE, 2014, 505 (7484) :559-+

[32] The role of n-3 PUFA-derived fatty acid derivatives and their oxygenated metabolites in the modulation of inflammation [J].

de Bus, Ian ;

Witkamp, Renger ;

Zuilhof, Han ;

Albada, Bauke ;

Balvers, Michiel .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2019, 144

[33] PBMCs express a transcriptome signature predictor of oxygen uptake responsiveness to endurance exercise training in men [J].

Dias, Rodrigo Goncalves ;

Moreira Silva, Michelle Sabrina ;

Duarte, Nubia Esteban ;

Bolani, Wladimir ;

Alves, Cleber Rene ;

Lemos Junior, Jose Ribeiro ;

da Silva, Jeferson Luis ;

de Oliveira, Patricia Alves ;

Alves, Guilherme Barreto ;

de Oliveira, Edilamar Menezes ;

Rocha, Cristiane Souza ;

Carneiro Marsiglia, Julia Daher ;

Negrao, Carlos Eduardo ;

Krieger, Eduardo Moacyr ;

Krieger, Jose Eduardo ;

Pereira, Alexandre Costa .

PHYSIOLOGICAL GENOMICS, 2015, 47 (02) :13-23

[34] Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth [J].

Doughty, Cheryl A. ;

Bleiman, Blair F. ;

Wagner, Dean J. ;

Dufort, Fay J. ;

Mataraza, Jennifer M. ;

Roberts, Mary F. ;

Chiles, Thomas C. .

BLOOD, 2006, 107 (11) :4458-4465

[35]

EISEMAN B, 1958, SURGERY, V44, P854

[36] NMR Spectroscopy for Metabolomics Research [J].

Emwas, Abdul-Hamid ;

Roy, Raja ;

McKay, Ryan T. ;

Tenori, Leonardo ;

Saccenti, Edoardo ;

Gowda, G. A. Nagana ;

Raftery, Daniel ;

Alahmari, Fatimah ;

Jaremko, Lukasz ;

Jaremko, Mariusz ;

Wishart, David S. .

METABOLITES, 2019, 9 (07)

[37] Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment [J].

Ertunc, Meric Erikci ;

Hotamisligil, Gokhan S. .

JOURNAL OF LIPID RESEARCH, 2016, 57 (12) :2099-2114

[38] Cardiorespiratory fitness as a predictor of intestinal microbial diversity and distinct metagenomic functions [J].

Estaki, Mehrbod ;

Pither, Jason ;

Baumeister, Peter ;

Little, Jonathan P. ;

Gill, Sandeep K. ;

Ghosh, Sanjoy ;

Ahmadi-Vand, Zahra ;

Marsden, Katelyn R. ;

Gibson, Deanna L. .

MICROBIOME, 2016, 4

[39] Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice [J].

Fujisaka, S. ;

Usui, I. ;

Ikutani, M. ;

Aminuddin, A. ;

Takikawa, A. ;

Tsuneyama, K. ;

Mahmood, A. ;

Goda, N. ;

Nagai, Y. ;

Takatsu, K. ;

Tobe, K. .

DIABETOLOGIA, 2013, 56 (06) :1403-1412

[40] Mechanisms of disease: Acute-phase proteins and other systemic responses to inflammation [J].

Gabay, C ;

Kushner, I .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (06) :448-454

← 1 2 3 4 5 6 7 8 9 10 →