Molecular Genetic Testing of Hemostasis and Thrombosis in Developing Countries: Achievements, Hopes, and Challenges

被引:0
作者
Ozeo, Margareth Castro [2 ]
Esp, Roman Zapata [3 ]
Qadura, Mohammad [1 ]
Chegeni, Rouzbah [4 ]
Othman, Maha [1 ]
机构
[1] Queens Univ, Richardson Lab, Dept Pathol & Mol Med, Kingston, ON K7L 3N6, Canada
[2] Univ Estadual Campinas, Hemoctr, Campinas, SP, Brazil
[3] Hosp Univ San Vicente Paul Medellin, Antioquia, Colombia
[4] Shahid Beheshti Univ Med Sci, Tehran, Iran
关键词
Developing countries; genetic testing; hemostasis; thrombosis;
D O I
10.1055/s-0028-1103368
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In today's developing world, how do we define a "developing country"? What level of effort and resources is invested in diagnosis, patient care, and research in those countries that we define to be developing? In particular, what is the situation with respect to Molecular genetic testing in these countries? How much has been achieved to date, and what are the challenges to further achievements? This article describes the Current status, challenges, and future hopes with respect to molecular genetic testing in hemostasis and thrombosis from the perspective of experts from three Countries: Brazil, Colombia, and It-an. These individuals have lived and practiced genetic testing in their Countries and have also had the experience to work and/or interact with the developed world to enable all appreciation of the difference.
引用
收藏
页码:569 / 578
页数:10
相关论文
共 46 条
  • [1] Glanzmann thrombasthenia and Bernard-Soulier syndrome in south Iran
    Afrabiasi, A
    Artoni, A
    Karimi, M
    Peyvandi, F
    Ashouri, E
    Mannucci, PM
    [J]. CLINICAL AND LABORATORY HAEMATOLOGY, 2005, 27 (05): : 324 - 327
  • [2] A novel splice site mutation in a Brazilian patient with hereditary antithrombin deficiency type I
    Arnaldi, LAT
    Polimeno, NC
    Arruda, VR
    Annichino-Bizzacchi, JM
    [J]. HUMAN HEREDITY, 1999, 49 (02) : 119 - 120
  • [3] FACTOR-V LEIDEN (FVQ-506) IS COMMON IN A BRAZILIAN POPULATION
    ARRUDA, VR
    ANNICHINOBIZZACCHI, JM
    COSTA, FF
    REITSMA, PH
    [J]. AMERICAN JOURNAL OF HEMATOLOGY, 1995, 49 (03) : 242 - 243
  • [4] Arruda VR, 1997, THROMB HAEMOSTASIS, V78, P1430
  • [5] ARRUDA VR, 1993, THROMB HAEMOSTASIS, V70, P371
  • [6] 11 NOVEL MUTATIONS IN THE FACTOR-VIII GENE FROM BRAZILIAN HEMOPHILIA-A PATIENTS
    ARRUDA, VR
    PIENEMAN, WC
    REITSMA, PH
    DEUTZTERLOUW, PP
    ANNICHINOBIZZACCHI, JM
    BRIET, E
    COSTA, FF
    [J]. BLOOD, 1995, 86 (08) : 3015 - 3020
  • [7] Admixture dynamics in Hispanics: A shift in the nuclear genetic ancestry of a South American population isolate
    Bedoya, Gabriel
    Montoya, Patricia
    Garcia, Jenny
    Soto, Ivan
    Bourgeois, Stephane
    Carvajal, Luis
    Labuda, Damian
    Alvarez, Victor
    Ospina, Jorge
    Hedrick, Philip W.
    Ruiz-Linares, Andres
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (19) : 7234 - 7239
  • [8] MUTATION IN BLOOD-COAGULATION FACTOR-V ASSOCIATED WITH RESISTANCE TO ACTIVATED PROTEIN-C
    BERTINA, RM
    KOELEMAN, BPC
    KOSTER, T
    ROSENDAAL, FR
    DIRVEN, RJ
    DERONDE, H
    VANDERVELDEN, PA
    REITSMA, PH
    [J]. NATURE, 1994, 369 (6475) : 64 - 67
  • [9] Collaborative research networks work
    Camargo, AA
    Simpson, AJG
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (04) : 468 - 471
  • [10] Factor V mutations in Iranian patients with activated protein C resistance and venous thrombosis
    Chegeni, Rouzbeh
    Kazemi, Bahram
    Hajifathali, Abbas
    Pourfathollah, AliAkbar
    Lari, Ghasem Rastegar
    [J]. THROMBOSIS RESEARCH, 2007, 119 (02) : 189 - 193