Nanofabricated upconversion nanoparticles for photodynamic therapy

被引：115
|
作者：
Ungun, Baris [1 ]
Prud'homme, Robert K. [2 ]
Budijono, Stephanie J. [1 ]
Shan, Jingning [2 ]
Lim, Shuang Fang [2 ,3 ]
Ju, Yiguang [2 ]
Austin, Robert [3 ]
机构：
[1] Princeton Univ, Dept Chem Engn, Princeton, NJ 08544 USA
[2] Princeton Univ, Dept Mech & Aerosp Engn, Princeton, NJ 08544 USA
[3] Princeton Univ, Dept Phys, Princeton, NJ 08544 USA
来源：
OPTICS EXPRESS | 2009年 / 17卷 / 01期
基金：
美国国家科学基金会;
关键词：
ORGANIC ACTIVES; SINGLET OXYGEN; ACID;
D O I：
10.1364/OE.17.000080
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We present a novel process for the production of three-layer Composite Nanoparticles (CNPs) in the size range 100-300 nm with an up-converting phosphor interior, a coating of porphyrin photosensitizer, and a biocompatible PEG outer layer to prevent clearance by the reticuloendothelial system. We show that these CNPs produce millimolar amounts of singlet oxygen at NIR intensities far less than other two-photon techniques. (C) 2008 Optical Society of America
引用
收藏
页码：80 / 86
页数：7
相关论文
共 50 条
  • [1] Recent Progress in Upconversion Photodynamic Therapy
    Qiu, Hailong
    Tan, Meiling
    Ohulchanskyy, Tymish Y.
    Lovell, Jonathan F.
    Chen, Guanying
    NANOMATERIALS, 2018, 8 (05)
  • [2] Protein modified upconversion nanoparticles for imaging-guided combined photothermal and photodynamic therapy
    Chen, Qian
    Wang, Chao
    Cheng, Liang
    He, Weiwei
    Cheng, Zhengping
    Liu, Zhuang
    BIOMATERIALS, 2014, 35 (09) : 2915 - 2923
  • [3] Efficacy Dependence of Photodynamic Therapy Mediated by Upconversion Nanoparticles: Subcellular Positioning and Irradiation Productivity
    Chen, Dexin
    Tao, Ran
    Tao, Ke
    Chen, Biqiong
    Choi, Seok Ki
    Tian, Qing
    Xu, Yawen
    Zhou, Guangdong
    Sun, Kang
    SMALL, 2017, 13 (13)
  • [4] Upconversion-based photodynamic cancer therapy
    Liu, Yanyan
    Meng, Xianfu
    Bu, Wenbo
    COORDINATION CHEMISTRY REVIEWS, 2019, 379 : 82 - 98
  • [5] Near-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticles
    Wang, Chao
    Tao, Huiquan
    Cheng, Liang
    Liu, Zhuang
    BIOMATERIALS, 2011, 32 (26) : 6145 - 6154
  • [6] Leveraging Spectral Matching between Photosensitizers and Upconversion Nanoparticles for 808 nm-Activated Photodynamic Therapy
    He, Sha
    Johnson, Noah J. J.
    Viet Anh Nguyen Huu
    Huang, Yuran
    Almutairi, Adah
    CHEMISTRY OF MATERIALS, 2018, 30 (12) : 3991 - 4000
  • [7] Inorganic Nanoparticles for Photodynamic Therapy
    Colombeau, L.
    Acherar, S.
    Baros, F.
    Arnoux, P.
    Gazzali, A. Mohd
    Zaghdoudi, K.
    Toussaint, M.
    Vanderesse, R.
    Frochot, C.
    LIGHT-RESPONSIVE NANOSTRUCTURED SYSTEMS FOR APPLICATIONS IN NANOMEDICINE, 2016, 370 : 113 - 134
  • [8] Lanthanide-doped upconversion nanoparticles electrostatically coupled with photosensitizers for near-infrared-triggered photodynamic therapy
    Wang, Meng
    Chen, Zhuo
    Zheng, Wei
    Zhu, Haomiao
    Lu, Shan
    Ma, En
    Tu, Datao
    Zhou, Shanyong
    Huang, Mingdong
    Chen, Xueyuan
    NANOSCALE, 2014, 6 (14) : 8274 - 8282
  • [9] Polymeric Nanoparticles for Cancer Photodynamic Therapy
    Conte, Claudia
    Maiolino, Sara
    Pellosi, Diogo Silva
    Miro, Agnese
    Ungaro, Francesca
    Quaglia, Fabiana
    LIGHT-RESPONSIVE NANOSTRUCTURED SYSTEMS FOR APPLICATIONS IN NANOMEDICINE, 2016, 370 : 61 - 112
  • [10] Functional organic nanoparticles for photodynamic therapy
    Lei-Lei Rui
    Hong-Liang Cao
    Yu-Dong Xue
    Li-Chao Liu
    Lei Xu
    Yun Gao
    Wei-An Zhang
    ChineseChemicalLetters, 2016, 27 (08) : 1412 - 1420
12345