Novel method for screening of enteric film coatings properties with magnetic resonance imaging

被引：13

作者：

Dorozynski, Przemyslaw ^{[1
]}

Jamroz, Witold ^{[1
]}

Niwinski, Krzysztof ^{[1
]}

Kurek, Mateusz ^{[1
]}

Weglarz, Wladyslaw P. ^{[2
]}

Jachowicz, Renata ^{[1
]}

Kulinowski, Piotr ^{[2
]}

机构：

[1] Jagiellonian Univ, Pharmaceut Fac, Dept Pharmaceut Technol & Biopharmaceut, PL-30688 Krakow, Poland

[2] Inst Nucl Phys PAN, Dept Magnet Resonance Imaging, PL-31342 Krakow, Poland

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2013年 / 456卷 / 02期

关键词：

Shellac; Enteric coating; Mini-tablets; Delayed release; Magnetic resonance imaging (MRI); Ultra-short echo time imaging (UTE); RELEASE; MICROSCOPY; POLYMERS; SHELLAC;

D O I：

10.1016/j.ijpharm.2013.08.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of the study is to present the concept of novel method for fast screening of enteric coating compositions properties without the need of preparation of tablets batches for fluid bed coating. Proposed method involves evaluation of enteric coated model tablets in specially designed testing cell with application of MRI technique. The results obtained in the testing cell were compared with results of dissolution studies of mini-tablets coated in fluid bed apparatus. The method could be useful in early stage of formulation development for screening of film coating properties that will shorten and simplify the development works. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：569 / 571

页数：3

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