Cognitive impairment is associated with elevated serum homocysteine levels among older adults

被引:32
作者
Kim, Sunghee [1 ]
Choi, Bo Youl [2 ]
Nam, Jung Hyun [3 ]
Kim, Mi Kyung [2 ]
Oh, Dong Hoon [4 ,5 ]
Yang, Yoon Jung [6 ]
机构
[1] Dongduk Womens Univ, Grad Sch Hlth Sci, Dept Clin Nutr, 60,Hwarang Ro 13 Gil, Seoul 02748, South Korea
[2] Hanyang Univ, Coll Med, Dept Prevent Med, 222 Wangsimni Ro, Seoul 04763, South Korea
[3] Hanyang Univ, Coll Med, Dept Psychiat, 222 Wangsimni Ro, Seoul 04763, South Korea
[4] Seulha Mental Hlth Clin, 2,Nohyeong 8 Gil 4F, Jeju Si 63083, Jeju Do, South Korea
[5] Hanyang Univ, Inst Hlth & Soc, 222 Wangsimni Ro, Seoul 04763, South Korea
[6] Dongduk Womens Univ, Coll Nat Sci, Dept Foods & Nutr, 60,Hwarang Ro 13 Gil, Seoul 02748, South Korea
基金
新加坡国家研究基金会;
关键词
Cognitive impairment; Folate; Vitamin B-12; Homocysteine; PLASMA HOMOCYSTEINE; PHYSICAL-EXERCISE; KOREAN VERSION; FOLATE STATUS; DEMENTIA; BRAIN; VITAMIN-B-12; DECLINE; NEUROGENESIS; INCREASES;
D O I
10.1007/s00394-017-1604-y
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
PurposeThe aim of this study was to examine the associations between the risk of cognitive impairment and the serum levels of folate, vitamin B-12, and homocysteine (Hcy).MethodsSubjects were persons aged 60-79years who participated in the Yangpyeong Cohort study between 2011 and 2012. Cognitive impairment and normal subjects consisted of 100 pairs of old adults matched by age, sex, and education levels. Cognitive function was evaluated with the Korean version of the Mini-Mental State Examination for Dementia Screening (MMSE-DS). Pearson's partial correlation coefficients and conditional multiple logistic regression analysis were applied to determine the associations between cognitive function and the serum levels of folate, vitamin B-12, and Hcy.ResultsCompared with the matched normal group, the cognitive impairment group had higher proportions of folate deficiency (<3ng/mL) and hyperhomocysteinemia (15 mu mol/L). Serum Hcy concentrations were inversely associated with serum folate (r=-0.234, p=0.001) and MMSE-DS score (r=-0.150, p=0.037) after adjusting for age, sex, and education. The high Hcy group showed a higher prevalence of cognitive impairment (4th vs. 1st quartile, OR 3.30, 95% CI 1.12-9.72, p for trend=0.014) after adjusting for exercise.ConclusionsThe present findings suggest a putative protective role of high serum folate and normal Hcy against cognitive impairment among older adults.
引用
收藏
页码:399 / 408
页数:10
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