Aceclofenac-loaded chitosan-tamarind seed polysaccharide interpenetrating polymeric network microparticles

被引：87

作者：

Jana, Sougata ^{[1
]}

Saha, Abhimunya ^{[1
]}

Nayak, Amit Kumar ^{[2
]}

Sen, Kalyan Kumar ^{[1
]}

Basu, Sanat Kumar ^{[1
]}

机构：

[1] Gupta Coll Technol Sci, Dept Pharmaceut, Asansol 713301, WB, India

[2] Seemanta Inst Pharmaceut Sci, Dept Pharmaceut, Mayurbhanj 757086, Odisha, India

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2013年 / 105卷

关键词：

Aceclofenac; Chitosan; Tamarind seed polysaccharide; Interpenetrating polymeric network; Sustained release; Drug delivery; CONTROLLED-RELEASE; IN-VITRO; DICLOFENAC SODIUM; MICROSPHERES; DELIVERY; BEADS; FORMULATION; MICROBEADS; CELLULOSE;

D O I：

10.1016/j.colsurfb.2013.01.013

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The present work deals with the preparation, characterization and evaluation of glutaraldehyde cross-linked chitosan-tamarind seed polysaccharide (TSP) interpenetrating polymeric network (IPN) microparticles for prolonged aceclofenac release. The drug entrapment efficiency of these microparticles was found 85.84 +/- 1.75 to 91.97 +/- 1.30% and their average particle sizes were ranged from 490.55 +/- 23.24 to 621.60 +/- 53.57 mu m. These chitosan-TSP IPN microparticles were characterized by FTIR. DSC, and SEM analyses. The in vitro drug release from these aceclofenac-loaded chitosan-TSP IPN microparticles showed sustained release of aceclofenac over 8 h and followed the Korsmeyer-Peppas model (R-2 = 0.9809-0.9828) with anomalous (non-Fickian) diffusion drug release mechanism. The in vivo studies exhibited sustained anti-inflammatory activity in carrageenan-induced rats over prolonged period after oral administration of these newly developed aceclofenac-loaded IPN microparticles. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：303 / 309

页数：7

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