RETRACTED: Two Zn(II)-based meta-organic frameworks: Selective detection of antibiotics and treatment activity on age-related macular degeneration by reducing inflammasome activation (Retracted Article)

Via utilizing the mixed-ligand method, two novel Zn(II)-containing meta-organic frameworks with the chemical formula of {[Zn(L)(5-HIP)]center dot H2O}(n)(1) and [Zn(L)(2,6-NDC)](n)(2) were prepared under the solvothermal conditions by applying aromatic dicarboxylic acids ligands (5-H2HIP = 5-hydroxyisophthalic acid; 2,6-H2NDC = 2,6-naphthalenedicarboxylic acid) and 1,4-bis(benzimidazol-1-yl)-2-butylene (L). Due to its good water stability as well as the strong luminescent emission around room temperature, complex2has the high selectivity and sensibility of fluorescence detection to the ceftriaxone sodium (a kind of antibiotic) with the detection limit up to ppm lever. The treatment activity of the compounds on age-related macular degeneration was assessed and the specific mechanism was investigated. First of all, the inflammasome activation in the endothelial cells of retina was evaluated with western blot. In addition to this, the down-stream production of the inflammasome activation was also measured with ELISA detection kit.