Erectile dysfunction and statin treatment in high cardiovascular risk patients

被引:63
|
作者
Solomon, H
Samarasinghe, YP
Feher, MD
Man, J
Rivas-Toro, H
Lumb, PJ
Wierzbicki, AS
Jackson, G
机构
[1] St Thomas Hosp, Ctr Cardiothorac, Dept Cardiol, London SE1 7EH, England
[2] Chelsea & Westminster Hosp, Beta Cell Diabet Ctr, London, England
[3] St Thomas Hosp, Dept Chem Pathol, London, England
关键词
angiotensin; 2; cardiovascular risk; erectile dysfunction; impotence; statin (HMG-CoA reductase inhibitor);
D O I
10.1111/j.1742-1241.2006.00793.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Erectile dysfunction (ED) has been associated with risk factors for atherosclerosis. Medications used for atherosclerosis have also been implicated in ED. The aim of this study is to investigate the relationship of erectile function to cardiovascular risk factors and specific drug therapies before and after 6 months of statin therapy. In this prospective observational study, International Index of Erectile Function (IIEF) scores were measured in 93 men attending cardiovascular risk clinics. Cardiovascular risk factors and drug therapies were assessed prior to initiation and after 6 months of statin therapy. Prior to statin therapy, the median IIEF score was 21 (range 0-25), and 57% had impairment of erectile function. After statin therapy, IIEF scores were reduced to 6.5 (range 0-25) (p < 0.001), and 22% experienced new onset ED. Before statin therapy no correlation was observed between IIEF score and any individual cardiovascular risk factor. After 6 months of statin therapy, correlations were observed between lower IIEF scores (r = 0.62; p < 0.001) and age and diabetes and weakly with smoking. Differences in dose, relative efficacy or relative lipophilicity of statin prescribed showed no correlation with change in IIEF score. This study suggests ED following statin therapy is more likely in patients with severe endothelial dysfunction due to established cardiovascular risk factors including age, smoking and diabetes.
引用
收藏
页码:141 / 145
页数:5
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