Sodium-glucose cotransporters: Functional properties and pharmaceutical potential

被引：112

作者：

Sano, Ryuhei ^{[1
]}

Shinozaki, Yuichi ^{[1
]}

Ohta, Takeshi ^{[2
]}

机构：

[1] Japan Tobacco Inc, Biol Pharmacol Res Labs, Cent Pharmaceut Res Inst, Takatsuki, Osaka, Japan

[2] Kyoto Univ, Lab Anim Physiol & Funct Anat, Grad Sch Agr, Kyoto, Japan

来源：

JOURNAL OF DIABETES INVESTIGATION | 2020年 / 11卷 / 04期

关键词：

Antidiabetic drugs; Sodium-glucose cotransporter 1; Sodium-glucose cotransporter 2; SGLT2 INHIBITOR EMPAGLIFLOZIN; AFFINITY NA+/GLUCOSE COTRANSPORTER; IMPROVED GLYCEMIC CONTROL; POSTPRANDIAL HYPERGLYCEMIA; DIABETIC-NEPHROPATHY; SELECTIVE INHIBITOR; TISSUE DISTRIBUTION; SUGAR TRANSPORTER; GENE-EXPRESSION; CARRIER SGLT1;

D O I：

10.1111/jdi.13255

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucose is the most abundant monosaccharide, and an essential source of energy for most living cells. Glucose transport across the cell membrane is mediated by two types of transporters: facilitative glucose transporters (gene name: solute carrier 2A) and sodium-glucose cotransporters (SGLTs; gene name: solute carrier 5A). Each transporter has its own substrate specificity, distribution, and regulatory mechanisms. Recently, SGLT1 and SGLT2 have attracted much attention as therapeutic targets for various diseases. This review addresses the basal and functional properties of glucose transporters and SGLTs, and describes the pharmaceutical potential of SGLT1 and SGLT2.

引用

页码：770 / 782

页数：13

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