Oxidative Stress in Cardiovascular Diseases and Obesity: Role of p66Shc and Protein Kinase C

被引：103
作者：
De Marchi, Elena [1 ]
Baldassari, Federica [1 ]
Bononi, Angela [1 ]
Wieckowski, Mariusz R. [2 ]
Pinton, Paolo [1 ]
机构：
[1] Univ Ferrara, Dept Morphol Surg & Expt Med, Sect Gen Pathol, Lab Technol Adv Therapies LTTA,ICSI, I-44121 Ferrara, Italy
[2] M Nencki Inst Expt Biol, Dept Biochem, PL-02093 Warsaw, Poland
来源：
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2013年 / 2013卷
关键词：
GLYCATION END-PRODUCTS; LIFE-SPAN DETERMINANT; LOW-DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; SUPEROXIDE-PRODUCTION; NADPH OXIDASE; ADIPOGENIC DIFFERENTIATION; ENDOTHELIAL DYSFUNCTION; VITAMIN-E; P66(SHC);
D O I：
10.1155/2013/564961
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Reactive oxygen species (ROS) are a byproduct of the normal metabolism of oxygen and have important roles in cell signalling and homeostasis. An imbalance between ROS production and the cellular antioxidant defence system leads to oxidative stress. Environmental factors and genetic interactions play key roles in oxidative stress mediated pathologies. In this paper, we focus on cardiovascular diseases and obesity, disorders strongly related to each other; in which oxidative stress plays a fundamental role. We provide evidence of the key role played by p66(Shc) protein and protein kinase C (PKC) in these pathologies by their intracellular regulation of redox balance and oxidative stress levels. Additionally, we discuss possible therapeutic strategies aimed at attenuating the oxidative damage in these diseases.
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页数：11
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