A follow-up study was done on the neurological handicap and intellectual development of high-risk infants with neonatal hypoglycemia. The frequency of neonatal hypoglycemia in high-risk infants is 8.6%, and the incidence of a major neurological handicap in high-risk infants with neonatal hypoglycemia is 11%. Risk factors for the handicap group are very low birthweight, intrauterine growth retardation, perinatal asphyxia and mothers with pregnancy-induced hypertension. Average DQ at 1.5 and 2.5 years and IQ at 4 and 6 years of very low birthweight infants with neonatal hypoglycemia showed no significant difference, in contrast to the control group.