Effect of new berberine derivatives on colon cancer cells

被引：46

作者：

Ortiz, Luis Miguel Guaman ^{[1
,2
]}

Croce, Anna Leta ^{[1
]}

Aredia, Francesca ^{[1
,3
]}

Sapienza, Simone ^{[1
]}

Fiorillo, Gaetano ^{[4
]}

Syeda, Tanjia Monir ^{[4
]}

Buzzetti, Franco ^{[4
]}

Lombardi, Paolo ^{[4
]}

Scovassi, Anna Ivana ^{[1
]}

机构：

[1] CNR, Ist Genet Mol, I-27100 Pavia, Italy

[2] Univ Tecn Particular Loja, Dept Ciencias Salud, Loja, Ecuador

[3] Univ Pavia, Dipartimento Biol & Biotecnol L Spallanzani, I-27100 Pavia, Italy

[4] Naxospharma Srl, Novate Milanese, Italy

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2015年 / 47卷 / 10期

关键词：

apoptosis; autophagy; berberine; colon cancer; fluorescence; AUTOPHAGY; AMPLIFICATION; MECHANISMS; APOPTOSIS; DEATH;

D O I：

10.1093/abbs/gmv077

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The natural alkaloid berberine has been recently described as a promising anticancer drug. In order to improve its efficacy and bioavailability, several derivatives have been designed and synthesized and found to be even more potent than the lead compound. Among the series of berberine derivatives we have produced, five compounds were identified to be able to heavily affect the proliferation of human HCT116 and SW613-B3 colon carcinoma cell lines. Remarkably, these active compounds exhibit high fluorescence emission property and ability to induce autophagy.

引用

页码：824 / 833

页数：10

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