Prion genotypes in Central America suggest selection for the V129 allele

被引：6

作者：

Hardy, J

Scholz, S

Evans, W

Goldfarb, L

Singleton, A

机构：

[1] NIA, Neurogenet Lab, Bethesda, MD 20892 USA

[2] NINDS, Clin Neurogenet Unit, NIH, Bethesda, MD 20892 USA

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2006年 / 141B卷 / 01期

基金：

英国医学研究理事会;

关键词：

prion; genetics; cannibalism;

D O I：

10.1002/ajmg.b.30248

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Using the well-characterized, human diversity sample series, we show that the V129 prion allele has a very high frequency in South American populations relative to the East Asian populations from which it arose. We suggest there has been selection at the prion locus, possibly mediated by Kuru-like diseases, which has influenced its allele frequency. (C) 2005 Wiley-Liss, Inc.

引用

页码：33 / 35

页数：3