Oxalates as Activating Groups for Alcohols in Visible Light Photoredox Catalysis: Formation of Quaternary Centers by Redox-Neutral Fragment Coupling

被引：314
作者：
Nawrat, Christopher C. [1 ]
Jamison, Christopher R. [2 ]
Slutskyy, Yuriy [2 ]
MacMillan, David W. C. [1 ]
Overman, Larry E. [2 ]
机构：
[1] Princeton Univ, Merck Ctr Catalysis, Princeton, NJ 08544 USA
[2] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 35期
基金：
美国国家科学基金会;
关键词：
TERTIARY RADICALS; ALKYL RADICALS; CLERODANE; FUNCTIONALIZATION; CONSTRUCTION; INVENTION; CARBONS;
D O I：
10.1021/jacs.5b07678
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Alkyl oxalates are new bench-stable alcohol-activating groups for radical generation under visible light photoredox conditions. Using these precursors, the first net redox-neutral coupling of tertiary and secondary alcohols with electron-deficient alkenes is achieved.
引用
收藏
页码：11270 / 11273
页数：4
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