Apolipoprotein E and alpha(1)-antichymotrypsin polymorphism in Alzheimer's disease

被引：36

作者：

Nacmias, B

Tedde, A

Latorraca, S

Piacentini, S

Bracco, L

Amaducci, L

Guarnieri, BM

Petruzzi, C

Ortenzi, L

Sorbi, S

机构：

[1] UNIV FLORENCE,DEPT NEUROL & PSYCHIAT SCI,I-50134 FLORENCE,ITALY

[2] ASSOC L PETRUZZI,CASA CURA VILLA SERENA,PESCARA,ITALY

来源：

ANNALS OF NEUROLOGY | 1996年 / 40卷 / 04期

关键词：

D O I：

10.1002/ana.410400420

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A recent observation has shown thar a common polymorphism in the alpha(1)-antichymotrypsin (ACT) gene modifies the apolipoprotein E (ApoE) epsilon 4-associated Alzheimer's disease (AD) risk identifying the combination of the ACT/AA. and ApoE epsilon 4/epsilon 4 genotypes as a potential susceptibility marker for AD, We analyzed the segregation of the ApoE and ACT polymorphism in sporadic and familial AD patients. in none of the sporadic AD patients did we find the combination of the ACT/AA, and ApoE epsilon 4/epsilon 4 genotypes. The frequency of ApoE epsilon 4/epsilon 4 homozygosity in the AD sample resulted highest far the ACT/TT genotype (17.6%). Our data fail to confirm any additional association with AD beyond the ApoE epsilon 4 allele with any ACT genotype, suggesting that ACT does not represent an additional risk factor for AD.

引用

页码：678 / 680

页数：3

共 50 条

[41] No association between alpha 1-antichymotrypsin and familial Alzheimer's disease [J].

Haines, JL ;

Pritchard, ML ;

Saunders, AM ;

Schildkraut, JM ;

Growdon, JH ;

Gaskell, PC ;

Farrer, LA ;

Auerbach, SA ;

Gusella, JF ;

Locke, PA ;

Rosi, BL ;

Yamaoka, L ;

Small, GW ;

Conneally, PM ;

Roses, AD ;

PericakVance, M .

APOLIPOPROTEIN E GENOTYPING IN ALZHEIMER'S DISEASE, 1996, 802 :35-41

[42] No association between the alpha 1-antichymotrypsin A allele and Alzheimer's disease [J].

Murphy, GM ;

Sullivan, EV ;

GallagherThompson, D ;

Thompson, LW ;

vanDuijn, CM ;

Forno, LS ;

Ellis, WG ;

Jagust, WJ ;

Yesavage, J ;

Tinklenberg, JR .

NEUROLOGY, 1997, 48 (05) :1313-1316

[43] Association between apolipoprotein E polymorphism and serum lipid and apolipoprotein levels with Alzheimer's disease [J].

Raygani, Asad Vaisi ;

Rahimi, Zohreh ;

Kharazi, Hadi ;

Tavilani, Haidar ;

Pourmotabbed, Tayebeh .

NEUROSCIENCE LETTERS, 2006, 408 (01) :68-72

[44] Relationship between Alzheimer′s,Parkinson′s disease and Apolipoprotein E polymorphism in the Chinese [J].

QIN Bin ZENG Xiang yu GUO Han bang TANG Wei qing XU Rong HE Jian xin WANG Shu XU Xian hao Deptof NeurologyBeijing HospitalBeijing ChinaBiochemistry DivisionInstitute of Gerontal Medicine .

白求恩医科大学学报, 2001, (05) :562-566

[45] Apolipoprotein E promoter polymorphism and sporadic Alzheimer's disease in a Japanese population [J].